ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor-Targeted Type-I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Unlocking Long-Lived Charge-Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modern Cyanine Dye-Based Photosensitizers for Medical Applications.Angewandte Chemie (International ed. in English) · 2026Review
- Twisted Intramolecular Charge Shuttle (TICS) Enables Ultrafast Ratiometric Sensing and Imaging of Nitrite.Angewandte Chemie (International ed. in English) · 2026Article
- Self-Adaptive Charge Transfer States in Aqueous Solutions Promote Fast Intersystem Crossing in a Photosensitizer for Tumor Inhibition.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Recent advances of cyanine dyes in tumor theranostics: molecular modification, delivery strategies, and synergistic mechanisms.RSC advances · 2026Review
- Article
- Engineering Carbon Nitride Quantum Dots via Sulfur Doping for Controlled Reactive Oxygen Species Generation.Global challenges (Hoboken, NJ) · 2026Article
- Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor-Targeted Type-I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
It is highly desired to achieve Type-I photosensitizer (PS) to overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy-atom-free Type-I PS T-BNCy5 is presented by incorporating a biotin-modified naphthalimide (NI) unit into the meso-position of a N-benzyl-functionalized, strongly photon-capturing pentamethine cyanine (Cy5) dye. Such molecular engineering induces a rigid orthogonal geometry between NI and Cy5 units by introducing an intramolecular sandwich-like π-π stacking assembly, which effectively promotes intersystem crossing (ISC) and greatly extends the triplet-state lifetime (τ = 389 µs), thereby markedly improving the superoxide (O
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.