Evidence map›Paper›PMID 40047189›Full record

ArticleJournal of periodontal & implant science2025

Bone regeneration and biosorption patterns of different bone substitutes: an

Seunghee Lee, Jungwoo Jung, Jungwon Lee, Young-Chang Ko, Dongseob Lee, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal & implant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seunghee LeeDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0009-0009-4567-3982
Jungwoo JungDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0009-0002-7851-4936
Jungwon LeeDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-5508-442X
Young-Chang KoDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0009-0006-1766-6740
Dongseob LeeDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0003-4146-3119
Ki-Tae KooDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-9809-2630
Yang-Jo SeolDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-2076-5452
Yong-Moo LeeDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. ymlee@snu.ac.kr.ORCID https://orcid.org/0000-0002-5619-3847

Funding

National Research Foundation of Korea 2022R1F1A1067588Purgo Biologics
6 · The paper itself

Abstract

purposeThis study aimed to analyze the bone regeneration and biosorption patterns of different bone substitutes in a rabbit skull defect model.

methodsFour circular 8 mm-defects were created in the cranium of 12 New Zealand white rabbits, each weighing approximately 3 kg. Each defect was randomly assigned to one of 4 treatment groups: cortical deproteinized porcine bone mineral (DPBM), cancellous DPBM, biphasic calcium phosphate (BCP) with a 6:4 ratio of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) (TCP4), and BCP with a 2:8 ratio of HA to β-TCP (TCP8). The rabbits were euthanized at either 6 weeks (n=6) or 12 weeks (n=6) post-surgery. The harvested specimens were then analyzed both radiographically and histomorphometrically.

resultsIn the micro-computed tomography analysis, no statistically significant differences were observed among the 4 groups, except in the bone graft volume/tissue volume (GV/TV) at 12 weeks. Cortical DBPM exhibited a higher GV/TV ratio than cancellous DBPM at the same time point. The histomorphometric analysis revealed increased biosorption in cancellous DBPM compared to cortical DBPM at 12 weeks. However, the percentage of newly formed bone did not significantly differ among the 4 groups.

conclusionsAll types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.

Indexed as

Biocompatible materialsBone regenerationBone substitutesMembranesSkullX-ray microtomography

Identifiers

PMID40047189
PMCPMC12230421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.