Trial reportJournal of cosmetic dermatology2025
Efficacy of Thermus thermophilus Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In Vitro Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Case Report: Paired vertex-occipital assessment reveals donor-area involvement in diffuse unpatterned alopecia.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAndrogenic alopecia (AGA) is a widespread form of hair loss characterized by the gradual reduction in follicular size and reduced hair density, with unsatisfactory treatments.
aimsThis study explores the therapeutic potential of a novel fermented extract, Thermus thermophilus fermentation extract (TTFE), in mitigating the effects of AGA.
methodsThe research integrates in vitro assays utilizing various hair-growth-related cells with a 12-week clinical trial involving 32 male subjects diagnosed with AGA. A 12-week clinical trial involving 32 male subjects diagnosed with AGA evaluated the effects of topical TTFE application on scalp hydration, transepidermal water loss (TEWL), sebum levels, and hair density using a hydration pin probe, tewameter, and sebumeter and a dermoscope respectively. Moreover, in vitro studies analyzed TTFE's effects on cell proliferation, ATP production, inflammation, key signaling pathways.
resultsThe study revealed that the topical administration of TTFE increased hair density (96.88%), follicular diameter (15%), and scalp hydration while reducing TEWL (47.43%) and sebum production (20%). The in vitro results corroborated these findings, showing that TTFE significantly enhanced hDPCs proliferation by increased ATP production and Ki67 expression, and upregulated β-catenin and downregulated TGF-β2. Additionally, TTFE demonstrated strong anti-inflammation by suppressing the proinflammatory cytokines IL-1β and IL-6 with decreased ROS.
conclusionsTTFE promotes hair growth and scalp health by improving follicles, modulating Wnt/β-catenin and TGF-β signaling, and reducing inflammation. These findings suggest TTFE holds promise as a potential treatment for AGA, offering a multifaceted approach to restoring hair growth and scalp health by targeting both follicular biology and inflammation.
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