Evidence map›Paper›PMID 40047072›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

IDOL Deficiency Inhibits Cholesterol-Rich Diet-Induced Atherosclerosis in Rabbits.

Tomonari Koike, Yui Koike, Manabu Niimi, Yanhong Guo, Dongshan Yang, Jun Song, Jie Xu, Xiangming Tang, Zhuoying Ren, Xiangbo Kong and 12 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Is IDOL an Ideal Target for Treating Atherosclerosis?Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Tomonari Koike *Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0003-4718-8234
Yui Koike *Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0002-4470-6350
Manabu Niimi *Department of Molecular Pathology, Faculty of Medicine, Graduate School of Interdisciplinary Research, University of Yamanashi, Japan (M.N., X.T., J.F.).ORCID 0000-0002-3694-5642
Yanhong GuoDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0002-3334-9159
Dongshan YangDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0003-2449-8651
Jun SongDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0002-6128-6378
Jie XuDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0001-9452-2878
Xiangming TangDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Interdisciplinary Research, University of Yamanashi, Japan (M.N., X.T., J.F.).ORCID 0000-0003-4082-7320
Zhuoying RenDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).
Xiangbo KongDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0002-4289-3172
Hongyu LiuDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).
Xiangjie ZhaoDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).
Tianqing ZhuDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).
Ruiting LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor (R.L., B.W., D.S.).
Bo WenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor (R.L., B.W., D.S.).ORCID 0000-0002-8337-220X
Duxin SunDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor (R.L., B.W., D.S.).
Oren RomDepartment of Pathology and Translational Pathobiology, Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center-Shreveport (O.R.).ORCID 0000-0002-9272-086X
Renzhi HanDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis (R.H.).
Jianglin FanDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Interdisciplinary Research, University of Yamanashi, Japan (M.N., X.T., J.F.).ORCID 0000-0002-1737-6130
Minerva T Garcia-BarrioDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0002-3381-3847
Jifeng ZhangDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0001-5161-4705
Y Eugene ChenDepartment of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor (T.K., Y.K., Y.G., D.Y., J.S., J.X., Z.R., X.K., H.L., X.Z., T.Z., R.R., M.T.G.-B., J.Z., Y.E.C.).ORCID 0000-0003-2357-7825

Funding

Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysmR01HL165688 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo, Anna Schwendeman · 2023 to 2026
$3.1M
IDOL and dyslipidemia in cardiovascular diseasesR01HL147527 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2019 to 2022
$3.1M
Nitro-Fatty Acids and Cardiovascular DiseaseR01HL162294 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE, GARCIA-BARRIO, MINERVA T · 2022 to 2025
$2.9M
Development of gene editing based therapy for cardiovascular diseasesR01HL159900 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE, HAN, RENZHI · 2021 to 2024
$2.8M
Vascular smooth muscle cell ferroptosis and abdominal aortic aneurysmR01HL166203 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo · 2023 to 2026
$2.7M
BAF60c and abdominal aortic aneurysmR01HL153710 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2021 to 2025
$2.7M
Controllable base editing therapy for DMDR01HL170260 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Renzhi Han · 2023 to 2026
$2.4M
Kruppel-like factor 11 (KLF11) and atherosclerosisR01HL138139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2017 to 2021
$2.3M
Targeted editing of ASGR1 for cardiovascular diseasesR01HL169976 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI YUQING Eugene CHEN, Renzhi Han · 2024 to 2026
$2.1M
Lipidated Amino Acids in Cardiometabolic DiseasesR01DK134011 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Oren Rom · 2022 to 2026
$2.1M
NHLBI NIH HHS K99 HL150233NHLBI NIH HHS R00 HL150233NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL138139NHLBI NIH HHS R01 HL147527NHLBI NIH HHS R01 HL153710NHLBI NIH HHS R01 HL159900NHLBI NIH HHS R01 HL162294NHLBI NIH HHS R01 HL165688NHLBI NIH HHS R01 HL166203NHLBI NIH HHS R01 HL169976NHLBI NIH HHS R01 HL170260NHLBI NIH HHS R21 HL163720NIDDK NIH HHS R01 DK134011NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

atherosclerosisdyslipidemiashuman geneticsprimatestriglycerides

Identifiers

PMID40047072
PMCPMC12018126

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.