Evidence map›Paper›PMID 40046988›Full record

ArticleComputational and structural biotechnology journal2025

Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants.

Karuna Anna Sajeevan, Bibek Acharya, Sakib Ferdous, Dan M Park, Joseph A Cotruvo, Ratul Chowdhury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karuna Anna SajeevanCenter for Biorenewable Chemicals, Iowa State University, Ames, IA, USA.
Bibek AcharyaDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Sakib FerdousDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Dan M ParkLawrence Livermore National Laboratory, Livermore, CA, USA.
Joseph A CotruvoDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Ratul ChowdhuryCenter for Biorenewable Chemicals, Iowa State University, Ames, IA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding rare earth element (REE) binding to proteins enables the engineering of selective protein-based ligands for precise REE recovery. Lanmodulin (LanM), with notable REE selectivity and picomolar binding affinity, is a promising candidate. This study shows that LanM variants employ distinct inter-residue interactions for REE binding. We detail the thermodynamics and structural aspects of binding events in wild-type (WT)

Indexed as

Binding affinityBinding distanceConformational space samplingInteraction energyLanmodulinMetal ion-protein binding

Identifiers

PMID40046988
PMCPMC11879702

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.