ReviewFrontiers in medicine2025
Endothelial dysfunction in chronic obstructive pulmonary disease: an update on mechanisms, assessment tools and treatment strategies.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Article
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Lung-Kidney Axis: A Coordinated Regulation of Oxygen Sensing and Erythropoiesis.Biomedicines · 2026Review
- Renal Dysfunction in Chronic Obstructive Pulmonary Disease Lung-Kidney Interorgan Crosstalk with Cardiac Mediation.International journal of molecular sciences · 2026Review
- Chronic Obstructive Pulmonary Disease as an Independent Predictor of Left Main Coronary Artery Disease.Medical sciences (Basel, Switzerland) · 2026Article
- Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation.International journal of chronic obstructive pulmonary disease · 2026Article
- Multi‑feature Prediction Model for Coronary Heart Disease Comorbidity in Middle‑aged and Older Adults with COPD Based on Machine Learning and SHAP.International journal of chronic obstructive pulmonary disease · 2026Article
- Association between the Endothelial Activation and Stress Index and all-cause mortality in patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2026Article
- COPD and Cardiovascular Diseases: Biomarker-Guided Stratification and Therapeutic Perspectives.Journal of clinical medicine · 2025Review
- Effects of dual bronchodilation on right ventricular function and troponin-I in newly diagnosed, moderate-to-severe chronic obstructive pulmonary disease: a prospective real-world observational study.Therapeutic advances in respiratory diseaseObservational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease (COPD) is a complex condition marked by chronic respiratory symptoms, such as cough and dyspnoea, and persistent irreversible airway obstruction, punctuated by acute episodes of exacerbations. COPD is associated with a significant mortality risk and several comorbidities, including cardiovascular diseases. The link between COPD, acute exacerbations and cardiovascular diseases has been recently acknowledged under the unifying concept of cardiopulmonary risk. In this context, endothelial dysfunction (ED) has been identified as a key contributor to the systemic manifestations of COPD and an early event in atherogenesis, thus potentially linking respiratory diseases and cardiovascular risk. Assessing endothelial dysfunction could therefore provide valuable prognostic insights into COPD, while targeting it may emerge as a promising therapeutic approach. Nonetheless, several aspects such as clinical assessment options and potential treatment strategies are still under debate, despite an intense research activity in recent years and promising results coming from the field of pulmonary rehabilitation medicine, which seems to be highly beneficial for the improvement of ED in COPD patients. On these premises, this mini review aims to provide an updated overview of the pathophysiology of ED in the context of COPD, with a focus on its assessment and its potential as an attractive therapeutic target.
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