ArticleOpen forum infectious diseases2025
Invasive Pneumococcal Disease and Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in Singapore Children Over 24 Years.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Practical Considerations Shaping Pneumococcal Vaccine Selection: A Multinational Cross-Sectional Survey of Healthcare Professionals.Infectious diseases and therapy · 2026Article
- Serotype diversity and risk factors for pneumococcal carriage among healthy children in Klang Valley, Malaysia: A pre-vaccination cross-sectional study.IJID regions · 2026Article
- Genomic characterization of invasive disease-causingMicrobial genomics · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Data on burden of invasive pneumococcal disease (IPD) are lacking from Southeast Asia. With the introduction of higher-valency pneumococcal conjugate vaccines (PCVs), we aim to assess the impact of PCV introduction into Singapore's National Childhood Immunisation Schedule (NCIS) on IPD burden and serotype replacement. Methods: Using IPD surveillance data from a single center, we compared the incidence of IPD in children aged <17 years before and after introduction of the PCV into the NCIS (2000-2009, period 1; 2010-2023, period 2). Results: The overall incidence of IPD from 2000 to 2023 was 3.9 per 100 000 children. The decline in IPD incidence between periods 1 and 2 was greatest in children aged ≤2 years (13.3 to 4.7/100 000 children; incidence rate ratio 0.4 [95% CI, .3-.5]; Conclusions: Introduction of PCV into Singapore's NCIS led to a substantial reduction in IPD burden in children aged ≤2 years. Serotype 19A continues to pose a challenge as a disease-causing serotype after PCV13 implementation in Singapore.
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