Evidence map›Paper›PMID 40046828›Full record

ArticleBMJ oncology2025

Long-term outcomes of bilateral salpingo-oophorectomy in women with personal history of breast cancer.

Hend Hassan, Tameera Rahman, Andrew Bacon, Craig Knott, Isaac Allen, Catherine Huntley, Lucy Loong, Yvonne Walburga, Eva Morris, Steven Hardy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hend HassanCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9375-0462
Tameera RahmanNational Disease Registration Service, London, London, UK.
Andrew BaconNational Disease Registration Service, London, London, UK.
Craig KnottHealth Data Insight CIC, Cambridge, UK.
Isaac AllenCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Catherine HuntleyNational Disease Registration Service, London, London, UK.
Lucy LoongNational Disease Registration Service, London, London, UK.ORCID 0000-0002-5933-027X
Yvonne WalburgaCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Eva MorrisBig Data Institute, University of Oxford, Oxford, UK.
Steven HardyNational Disease Registration Service, London, London, UK.
Bethany TorrDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Diana M EcclesUniversity of Southampton, Southampton, UK.
Clare TurnbullDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Marc TischkowitzDepartment of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
Paul PharoahCedars-Sinai Medical Center, Los Angeles, California, USA.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the association between bilateral salpingo-oophorectomy (BSO) and long-term health outcomes in women with a personal history of breast cancer. Methods and analysis: We used data on women diagnosed with invasive breast cancer between 1995 and 2019 from the National Cancer Registration Dataset (NCRD) in England. The data were linked to the Hospital Episode Statistics-Admitted Patient Care dataset to identify BSO delivery. Long-term health outcomes were selected from both datasets. Multivariable Cox regression was used to examine the associations, with BSO modelled as a time-dependent covariate. The associations were investigated separately by age at BSO. Results: We identified 568 883 women, 23 401 of whom had BSO after the breast cancer diagnosis. There was an increased risk of total cardiovascular diseases with an HR of 1.10 (95% CI 1.04 to 1.16) in women who had BSO<55 years and 1.07 (95% CI 1.01 to 1.13) for women who had BSO≥55 years. There was an increased risk of ischaemic heart diseases, but there was no association with cerebrovascular diseases. BSO at any age was associated with an increased risk of depression (HR 1.20, 95% CI 1.12 to 1.28) and increased risk of second non-breast cancer in older women (HR 1.21, 95%CI 1.08 to 1.35). BSO in older women was associated with reduced risk of all-cause mortality (HR 0.92, 95% CI 0.87 to 096), but not in women who had BSO<55 years. Conclusion: In women with a personal history of breast cancer, BSO before and after the age of 55 years is associated with an increased risk of long-term outcomes. BSO after 55 years is associated with reduced all-cause mortality. Family history or genetic predisposition may confound these associations.

Indexed as

Breast cancer (female)EpidemiologyOvarian cancerSurgical oncology

Identifiers

PMID40046828
PMCPMC11880784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.