Evidence map›Paper›PMID 40046812›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research.

Ziqian Li, Junyu Yan, Xiang Li, Hui Chen, Chen Lin, Yuhang Zhang, Tian Gao, Yabo Zhang, Yue Shu, Shuyuan Pan and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziqian Li *Beijing Institute of Biological Products Company Limited, Beijing, China.
Junyu Yan *Beijing Institute of Biological Products Company Limited, Beijing, China.
Xiang LiBeijing Institute of Biological Products Company Limited, Beijing, China.
Hui ChenBeijing Institute of Biological Products Company Limited, Beijing, China.
Chen LinBeijing Institute of Biological Products Company Limited, Beijing, China.
Yuhang ZhangBeijing Institute of Biological Products Company Limited, Beijing, China.
Tian GaoBeijing Institute of Biological Products Company Limited, Beijing, China.
Yabo ZhangBeijing Institute of Biological Products Company Limited, Beijing, China.
Yue ShuBeijing Institute of Biological Products Company Limited, Beijing, China.
Shuyuan PanBeijing Institute of Biological Products Company Limited, Beijing, China.
Yuntao ZhangBeijing Institute of Biological Products Company Limited, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological and pathological processes. Their ubiquitous presence in bodily fluids and cell-specific characteristics make them promising candidates as biomarkers. Additionally, their ability to transport biological therapeutics across different biological barriers to specific target cells underscores their significant translational potential for diagnostic and therapeutic purposes. Significant progress has been achieved in the translation of EVs research to clinical applications, however, challenges persist in the large-scale production of EVs, particularly in the areas of scalable manufacturing, efficient isolation methods, drug loading techniques, and advanced characterization technology. This review critically examines the complex processes involved in EVs biogenesis and explores recent developments in large-scale EVs production. By synthesizing knowledge from these fields, this review aims to provide a holistic perspective on the evolving landscape of EVs research and its applications, underscoring both the accomplishments and the obstacles that lie ahead in fully realizing the potential of EVs in biomedicine.

Indexed as

biomarkerscharacterizationdrug deliveryextracellular vesicleslarge-scale production

Identifiers

PMID40046812
PMCPMC11879961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.