ArticleInternational journal of health sciences
Zingerone mitigates metabolic dysfunction and alters pro-opiomelanocortin gene expression in offspring of high-fat diet-fed pregnant wistar rats.
Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Methods: 30 pregnant Wistar rats were divided into five groups: Normal control group, an HFD control, and three experimental groups treated with 50, 100, or 200 mg/kg of zingerone, respectively. The treatment commenced from day 1 of pregnancy until postnatal day (PND) 21, after which the offsprings were weaned and placed on a standard diet until PND 42. On PND 42, the biochemical assays were performed on the offsprings using enzyme-linked immunosorbent assay kits and the hypothalamic POMC gene expression using reverse transcription polymerase chain reaction. Data were analyzed using analysis of variance. Values of Results: Offsprings in the zingerone-treated groups showed significant ( Conclusion: Maternal zingerone administration may mitigate the risk of metabolic disorders in the offspring, possibly by its influence on the anorexigenic genetic makeup of the offspring.
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40046792PMC11877057What OpenQuestion holds
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