SynthesisFrontiers in pharmacology2025
Add-on effects of total glucosides of paeony on conventional therapies for psoriasis: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of plant-derived bioactive compounds in the treatment of psoriasis vulgaris: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psoriasis is an inflammatory and recurrent dermatological disease that is associated with multiple comorbidities. Conventional psoriasis therapies such as acitretin capsule and narrow-band ultraviolet B radiation (NB-UVB) are prone to decreased efficacy and adverse events in long-term application. Total glucosides of paeony (TGP), a plant extract from Radix Paeoniae Alba, are commonly used in conjunction with conventional therapies for psoriasis. This study aims to elucidate the add-on effect of TGP on conventional therapies in the treatment of psoriasis. Methods: Seven databases were searched from their inception to March 2024. Randomized controlled trials (RCTs) using TGP in conjunction with conventional therapies for psoriasis were included. The Risk of Bias 2.0 (RoB 2.0) tool was used to assess bias risk, and data analysis was conducted using RevMan V.5.4. Evaluation outcomes mainly involved a 60% or greater reduction of Psoriasis Area and Severity Index score (PASI 60) and a 50% or greater reduction of Psoriasis Area and Severity Index score (PASI 50). Results: This meta-analysis ultimately included 36 RCTs with 3,140 participants. The findings indicated that TGP combined with conventional therapies were superior to conventional therapies used alone on PASI 60 (RR = 1.32, 95% CI: 1.25 to 1.39, Conclusion: This meta-analysis demonstrated the preliminary clinical evidence supporting the addition of TGP to conventional therapies in treating psoriasis. Owing to the limited methodological quality of the included studies, well-designed RCTs are required to further illustrate the add-on effect of TGP on conventional therapies for psoriasis. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=439904, identifier CRD42023439904.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.