ArticleIndian journal of anaesthesia2025
Comparison of desflurane and sevoflurane as maintenance inhalational anaesthetic agents for adult patients undergoing neurosurgeries: A systematic review and meta-analysis of randomised trials.
Article in Indian journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Association between the EU desflurane phase-out and secondary market vaporizer prices: An observational time-series analysis.Journal of anesthesia and translational medicine · 2026Article
- Beyond a hasty ban: a call for a nuanced approach to desflurane use in Japanese anesthesia practice.Journal of anesthesia · 2026Article
- The effects of desflurane on male rat reproductive hormones, testicular tissue, and sperm morphology: an experimental study.BMC anesthesiology · 2026Article
- Protecting clinician autonomy and patient safety within the climate debate: the case for desflurane in modern anaesthesia.Current opinion in anaesthesiology · 2026Review
- Assessment of GRADE utilisation in published systematic review and meta-analysis.Indian journal of anaesthesia · 2026Article
- Automated tools in systematic reviews: Current trends.Indian journal of anaesthesia · 2025Article
- Acute and Subacute Oral Toxicity Assessment of Kinkeliba (Plants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Despite its superior blood-gas partition coefficient compared to sevoflurane, use of desflurane in neurosurgery is limited due to concerns about cerebral vasodilation and potential adverse haemodynamic effects. This study aims to systematically evaluate the comparative efficacy and safety of desflurane and sevoflurane in neurosurgical procedures. Methods: A search was performed in the Cochrane Library, Scopus, Europe PMC and Medline databases for articles published until 5 November 2024 using a combination of pertinent keywords. This review includes randomised controlled trials (RCTs) that analyse the comparison between desflurane and sevoflurane in neurosurgery. The risk of bias from each RCT was assessed using the Risk of Bias version 2 tool from Cochrane Collaboration. We utilised random-effects models to evaluate the mean difference (MD) and odds ratio (OR) for the outcomes presented. Results: Fourteen trials, encompassing 904 patients, were included in the analysis. Our analysis revealed significantly faster recovery profiles with desflurane, including reduced emergence time [MD -2.26; 95% confidence interval (CI): -2.99, -1.52, Conclusion: This study suggests that desflurane anaesthesia offers faster recovery with a similar safety profile to sevoflurane for neurosurgery.
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