ArticleFrontiers in neurology2025
Unraveling progressive verbal memory deficits in Huntington's disease: insights from the LASSI-L.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Memory Function and Huntington's Disease: A Systematic Review.Neuropsychology review · 2025Review
- Toward a Speech-Based Model of Premanifest Huntington's Disease Progression Using Deep Neural Networks.Digital biomarkersArticle
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8 authors.
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Abstract
Background and objectives: Huntington's disease (HD) is characterized by progressive cognitive decline, with early deficits often preceding motor symptoms. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) captures many types of deficits in verbal memory including susceptibility to interference. The current study aims to delineate the progression of these deficits across different stages of HD. Methods: 151 participants (89 HD, 62 healthy controls) were recruited across three sites. HD participants were classified into three groups using a PIN score and TMS: >10 years from manifest HD, <10 years from manifest HD, and manifest HD. Group comparisons on the LASSI-L were assessed using multiple ANCOVAs adjusting for age, followed by post-hoc pairwise comparisons and a Bonferroni correction. Results: Sequential group differences for susceptibility to interference effects were observed on the LASSI-L. Proactive Semantic Interference (PSI) deficits emerged >10 years before manifest HD, Failure to Recover from PSI ( Discussion: The LASSI-L appears to be a useful tool for detecting early and progressive cognitive changes in Huntington's disease, particularly by capturing the sequential nature of verbal memory deficits, including early vulnerability to interference. These findings suggest that the LASSI-L may help refine HD staging by integrating sequential neuropsychological markers of cognitive decline.
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