Evidence map›Paper›PMID 40046635›Full record

ArticleToxicology reports2025

MnTBAP, a peroxynitrite scavenger, attenuates cisplatin-induced apoptosis and cytotoxicity in organ of Corti cells.

Monazza Shahab, Rita Rosati, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monazza ShahabInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Rita RosatiInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Pankaj BhatiaInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Nicole Doyon-RealeInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Samson JamesdanielInstitute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.

Funding

Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
Targeting nitrative stress for treatment of cisplatin ototoxicityR01DC020299 · NIDCD · WAYNE STATE UNIVERSITY · PI SAMSON JAMESDANIEL · 2023 to 2026
$1.4M
NIDCD NIH HHS R01 DC020299NIEHS NIH HHS P30 ES020957
6 · The paper itself

Abstract

Cisplatin, a widely used anti-cancer drug, induces apoptosis in cochlear hair cells. In previous studies, cisplatin-induced nitration and degradation of proteins such as LMO4 disrupted their anti-apoptotic signaling. Cotreatment with SRI110, a peroxynitrite decomposition catalyst, attenuated cisplatin-induced ototoxicity in rodents. However, it is not known if other compounds that target nitrative stress would also confer similar otoprotection. Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a cell-permeable superoxide dismutase mimetic, is a peroxynitrite decomposition catalyst that selectively scavenges peroxynitrite. This study demonstrates that cotreatment of UB/OC1 cells MnTBAP prevented cisplatin-induced cytotoxicity and nitrative stress. Furthermore, the mRNA levels of pro-apoptotic genes such as

Indexed as

ApoptosisCisplatinMnTBAPOtotoxicityUB/OC-1 cell lines

Identifiers

PMID40046635
PMCPMC11880612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.