ArticleFrontiers in oncology2025
Pilot study of an arterial enhancement fraction-based model for progression prediction in HCC undergoing chemoembolization.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop a prognostic model including arterial enhancement fraction of residual tumor (AEF-RT) for predicting progression-free survival (PFS) in hepatocellular carcinoma (HCC) patients after drug-eluting beads transarterial chemoembolization (DEB-TACE). Materials and methods: Between March 2019 and March 2024, 111 HCC patients undergoing DEB-TACE were randomly allocated to a training cohort and a validation cohort in a 7:3 ratio. LASSO regression was applied in the training cohort to identify risk factors for recurrence, which were subsequently used to construct the Cox model. Model performance was assessed using the concordance index (C-index, where 0.5 indicates non-informative discrimination and 1 represents perfect discrimination) and Brier score (ranging from 0 to 1, 0 indicating higher calibration) and was compared with five existing prognostic models. Results: The final model, termed ADMAN model, incorporated AEF-RT, Diameter, Margin appearance, Aspartate transaminase, and Neutrophil-to-lymphocyte ratio. High-risk patients defined by ADMAN had 4.69 times greater progression risk than low-risk ones in the training cohort ( Conclusions: The AEF-based model may be a promising tool for progression risk stratification in HCC patients undergoing DEB-TACE. Further external validation in independent cohorts with larger sample sizes is necessary to confirm the robustness of the ADMAN model.
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