Evidence map›Paper›PMID 40046621›Full record

ArticleFrontiers in oncology2025

Virusplot: a web server for viral integration analysis and visualization.

Erqiang Hu, Jianhong An, Adam J Gersten, Nicole Wu, Nicole Kawachi, Jing Zhu, Gregory Rosenblatt, Stelby Augustine, Richard V Smith, Jeffrey E Segall and 7 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erqiang HuDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Jianhong AnDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Adam J GerstenDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Nicole WuThe University of Texas at Austin, Austin, TX, United States.
Nicole KawachiDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Jing ZhuDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Gregory RosenblattDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Stelby AugustineDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.
Richard V SmithDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.
Jeffrey E SegallDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Harry OstrerDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Antonio L AmelioDepartment of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.
Christine H ChungDepartment of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.
Michael B PrystowskyDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Thomas J OwDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Wenjun DengDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Shanye YinDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.

Funding

Dissecting Tumor-Immune Interactions in HIV-HPV Co-Infection-Associated Oropharyngeal Cancer using Single Cell Sequencing and Novel Mouse ModelsR01CA291607 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HARRIS GOLDSTEIN, Shanye Yin · 2024 to 2026
$1.7M
The Role of Red Blood Cell in Stroke-Related HyperglycemiaR01NS134819 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Wenjun Deng, Eng H. Lo · 2024 to 2026
$1.3M
Defining the impact of mutational drivers on the immune microenvironment of CLLR21CA267527 · NCI · DANA-FARBER CANCER INST · PI WU, CATHERINE JU-YING, YIN, SHANYE · 2022 to 2023
$454k
Red Blood Cell BPGM Deficiency Contributes to Cognitive Impairment Following Ischemic StrokeR21NS140800 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Wenjun Deng · 2025 to 2026
$441k
NCI NIH HHS R01 CA291607NCI NIH HHS R21 CA267527NINDS NIH HHS R01 NS134819NINDS NIH HHS R21 NS140800
6 · The paper itself

Abstract

The integration of viral DNA into the human genome is a critical event in the pathogenesis of various cancers. This process leads to genomic instability, disrupts cellular regulatory mechanisms, and activates oncogenes or inactivates tumor suppressor genes. Despite significant advancements in genome sequencing technologies, there remains a notable lack of computational tools, particularly web-based applications, specifically designed for viral integration analysis and visualization. To address this gap, we present virusPlot, a web server with the following functional modules: (i) automatic retrieval of virus genome sequences and their annotation; (ii) visualization of virus integration locations and read counts through a graphical representation that links viral and host genome integration sites, facilitating the interpretation of integration patterns; (iii) analysis of virus integration hotspots using Fisher's exact test; and (iv) integration of various functions into an interactive web platform via shinyapp. VirusPlot efficiently processes and visualizes integration data from viruses and host genomes, providing researchers with an intuitive and user-friendly analytical tool that simplifies the complexity of virus integration analysis.

Indexed as

bioinformatics toolcomputational biologygenomic visualizationhost-virus interactionhotspot analysisviral integration

Identifiers

PMID40046621
PMCPMC11880266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.