Evidence map›Paper›PMID 40046525›Full record

ArticleAnnals of gastroenterological surgery2025

Treatment outcomes of hepatectomy and systemic chemotherapy based on oncological resectability criteria for hepatocellular carcinoma.

Shohei Komatsu, Yoshihiko Yano, Nobuaki Ishihara, Masahiro Kido, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto

Abstract read
In one paragraph

Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shohei KomatsuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.ORCID https://orcid.org/0000-0001-9059-2473
Yoshihiko YanoDivision of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Nobuaki IshiharaDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Masahiro KidoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Hidetoshi GonDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Kenji FukushimaDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Takeshi UradeDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Hiroaki YanagimotoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.ORCID https://orcid.org/0000-0001-6493-4732
Hirochika ToyamaDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.
Takumi FukumotoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery Kobe University Graduate School of Medicine Kobe Hyogo Japan.ORCID https://orcid.org/0000-0003-1592-4524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The oncological resectability criteria for hepatocellular carcinoma (HCC) have recently been established (R/BR1/BR2), and validating the outcomes is an urgent issue. This study aimed to analyze the outcomes of hepatectomy and systemic chemotherapy based on the oncological resectability criteria. Methods: A total of 931 patients in the hepatectomy group and 273 in the systemic chemotherapy group who received atezolizumab/bevacizumab, lenvatinib, or durvalumab plus tremelimumab were recruited. Results: The median survival times (MST) in the hepatectomy group were R, 107.2 mo; BR1, 44.4 mo; and BR2, 18.4 mo ( Conclusion: The oncological resectability criteria for HCC effectively stratified the prognosis after hepatectomy. Treatment outcomes of hepatectomy in patients with two to three BR2-defining factors are limited, suggesting the need for multidisciplinary treatment.

Indexed as

borderline resectablehepatectomyhepatocellular carcinomaoncological resectability criteriasystemic chemotherapy

Identifiers

PMID40046525
PMCPMC11877347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.