ArticleFrontiers in veterinary science2025
Metabolic and immune profiles of 1-year and 2.5+ year-old white leghorn roosters following intramuscular lipopolysaccharide injection.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Immune cell profile and metabolic preference following intramuscular lipopolysaccharide injection of highly inbred and advanced intercross genetic lines.Frontiers in veterinary science · 2025Article
- Genetic line-specific immune profiles and immunometabolic responses to intramuscular lipopolysaccharide injection.Frontiers in immunology · 2025Article
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Authors and funding
2 authors.
Funding
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Abstract
Aerosolized endotoxins such as Lipopolysaccharide (LPS), found in livestock environments, induce an inflammatory mediator cascade. Poultry are commonly exposed to LPS over the growth cycle; however, little is known regarding the cumulative impact of intramuscular LPS injection and its effects on immune cellular metabolism, pathway preferences, and clearance response. Utilizing a LPS model in chickens can offer insight into host immune responses and provide a better understanding of immune tolerance to this endotoxin and major component of Gram-negative bacteria. Therefore, the study objectives were to compare metabolic phenotypes and immune profiles of isolated peripheral blood mononuclear cells (PBMC) from two ages of adult White Leghorn roosters before and post-LPS injection. A total of 20 adult White Leghorn roosters aged 1 yr. or 2.5+ yrs. were randomly assigned to sterile saline or 1 mg/kg body weight LPS (
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