ArticleFrontiers in veterinary science2025
Effects of trans-mitral flow patterns and heart rate on intraventricular pressure gradients and E/E' in the early stage of a rat model of hypertensive cardiomyopathy.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- An Innovative Artificial Intelligence Classification Model for Non-Ischemic Cardiomyopathy Utilizing Cardiac Biomechanics Derived from Magnetic Resonance Imaging.Bioengineering (Basel, Switzerland) · 2025Article
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11 authors.
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Abstract
Background: The mitral inflow spectral is expressed as two separate waves: early diastolic trans-mitral flow velocity (E) and late diastolic trans-mitral flow velocity (A) waves. When the heart rate (HR) increases and the diastolic time diminishes, the mitral flow pattern changes from EA-separation to EA-fusion. The E wave provides information about preload and diastolic function. Tissue Doppler imaging (TDI) and non-invasive intraventricular pressure gradient (IVPG) based on color-M-mode echocardiography are two techniques established in recent years with good repeatability in cardiac function evaluation, especially diastolic. Hypothesis/objective: We hypothesize that IVPG and E/E' are differentially influenced by mitral inflow patterns. Animals: A total of 66 hypertensive cardiomyopathy (HTN-CM) induced by abdominal aorta coarctation and 33 sham-operated rats were divided into 6 groups according to trans-mitral flow patterns. Methods: Conventional echocardiography, TDI, and IVPG sampling were performed on rats under general anesthesia with 2.5% isoflurane at 3 weeks after the operation. After code EA-separation = 1, EA-half-separation = 2, and EA-fusion = 3, Pearson's correlation tests were performed. Results: Both E and E' in EA-fusion (1.04 ± 0.13 and 7.65 ± 0.84) are higher than the EA-separation pattern in all rats (0.91 ± 0.10 and 5.51 ± 0.78, Conclusion: The mitral inflow pattern positively correlates with basal IVPG, E, and E'. Mid-to-apical IVPG was independent of mitral inflow patterns, while E/E' tended to be lower when the mitral inflow pattern changed from EA-separation to EA-fusion.
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