Evidence map›Paper›PMID 40046342›Full record

ArticleBrain communications2025

Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories.

Vilma Alanko, Sára Mravinacová, Anette Hall, Göran Hagman, Rosaleena Mohanty, Eric Westman, Peter Nilsson, Miia Kivipelto, Anna Månberg, Anna Matton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vilma AlankoDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9918-9429
Sára MravinacováDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, SE-171 65 Stockholm, Sweden.ORCID https://orcid.org/0000-0003-1848-910X
Anette HallDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Göran HagmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0003-0238-8646
Rosaleena MohantyDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0001-6499-1251
Eric WestmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3115-2977
Peter NilssonDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, SE-171 65 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-4657-8532
Miia KivipeltoDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0003-0992-3875
Anna MånbergDivision of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, SE-171 65 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-0056-1313
Anna MattonDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7819-0495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease and related dementias have a multifactorial aetiology and heterogeneous biology. The current study aims to identify different biological signatures in a deeply phenotyped memory clinic patient population. In this cross-sectional study, we analysed 49 pre-specified proteins using a multiplex antibody-based suspension bead array in 278 CSF samples from the real-world research database and biobank at the Karolinska University Hospital Memory Clinic, Solna, Sweden. Patients with a clinical diagnosis of subjective cognitive decline (

Indexed as

Alzheimer's diseasebiomarkersbiosignaturecognitionprotein profiling

Identifiers

PMID40046342
PMCPMC11881062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.