Evidence map›Paper›PMID 40046334›Full record

ArticleBrain communications2025

Integrating genome-wide association studies and transcriptomics prioritizes drug targets for meningioma.

Wan-Zhe Liao, Jia-He Wang, Hua-Jie Zhong, Shen-Yu Wen, Yang Chen, Jia-Qi Chen, Xue-Kun Zhang, Xin-Yi Wu, Jia-Nuo Tan, Kun-Yi Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wan-Zhe LiaoNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Jia-He WangNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Hua-Jie ZhongNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Shen-Yu WenNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Yang ChenNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Jia-Qi ChenNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Xue-Kun ZhangNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Xin-Yi WuNanshan College of Guangzhou Medical University, Guangzhou 511436, China.
Jia-Nuo TanSchool of Stomatology, Guangzhou Medical University, Guangzhou 510182, China.
Kun-Yi LiThe First Affiliated Hospital of Chengdu Medical College, Chengdu 610513, China.
Shao-Cong MoDepartment of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China.
Li-Jun WangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningioma, a prevalent central nervous system tumour, presents a significant challenge in neuro-oncology. This study harnesses genome-wide association studies (GWAS) and transcriptomic analysis to illuminate the pathological underpinnings of meningioma and spearhead the discovery of novel drug targets. By employing summary-data-based Mendelian randomization (SMR), colocalization analyses and Mendelian randomization, we pinpointed four genes as pivotal therapeutic targets. The integration of bulk and single-cell RNA sequencing confirmed the upregulated expression of three of the genes (

Indexed as

drug targetsmeningiomaneuro-oncologysingle-cell sequencing

Identifiers

PMID40046334
PMCPMC11880806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.