Evidence map›Paper›PMID 40046266›Full record

ArticleJOR spine2025

Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions.

Hans-Joachim Wilke, Annette Kienle, Karin Werner, Christian Liebsch

Abstract read
In one paragraph

Article in JOR spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Intervertebral disc degeneration.Nature reviews. Disease primers · 2026
    Review
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  10. Can cervical disc herniations be provokedFrontiers in bioengineering and biotechnology · 2026
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hans-Joachim WilkeInstitute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm Ulm University Medical Centre Ulm Germany.ORCID https://orcid.org/0000-0001-6007-8844
Annette KienleSpineServ GmbH & Co. KG Ulm Germany.
Karin WernerInstitute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm Ulm University Medical Centre Ulm Germany.
Christian LiebschInstitute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm Ulm University Medical Centre Ulm Germany.ORCID https://orcid.org/0000-0003-1543-4728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spinal flexibility can vary among spinal sections and single motion segments. The purpose of this work was to provide a comprehensive overview of the range of motion (RoM) and neutral zone (NZ) values of all spinal levels collected during 30 years of in vitro experiments under standardized testing conditions. Methods: RoM and NZ data obtained from in vitro testing of intact human mono- and polysegmental specimens with pure moments of 2.5 Nm for the cervical, 5 Nm for the thoracic, and 7.5 Nm for the lumbar spine were collated from the internal database of the authors' institution. Descriptive statistics were performed with median values and median absolute deviations. Outliers were defined as values beyond twofold standard deviation and excluded from evaluation. Normal distribution was verified using the Shapiro-Wilk test. Results: RoM and NZ data of Conclusions: This unique summary of RoM and NZ data, acquired under the same loading conditions in the same spine tester, provides a detailed insight into overall spinal flexibility and will serve as a valid dataset for the validation of in vitro studies and numerical models of the single motion segments of the spine.

Indexed as

biomechanicscervicalflexibilityhumanin vitrolumbarneutral zonerange of motionspinethoracic

Identifiers

PMID40046266
PMCPMC11881816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.