Evidence map›Paper›PMID 40046257›Full record

ArticleMediators of inflammation2025

Interleukins-27 Aggravates Liver Injury by Impairing the Antimicrobial Response of Macrophages via the Promotion of Mitochondrial Dysfunction in the Context of Sepsis.

Yuehua You, Yuyan Li, Lin Ye, Fang Xu, Jing Fan

Abstract read
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuehua YouDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuyan LiDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lin YeDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0009-7935-6547
Fang XuDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-8201-1595
Jing FanDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0003-4978-9455

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Interleukin-27InterleukinsMacrophagesMitochondriaSepsisAnimalsLipopolysaccharidesLiverMaleMiceMice, Inbred C57BLMice, KnockoutPhagocytosisPyroptosisRAW 264.7 CellsIl27 protein, mouseInterleukin-27InterleukinsLipopolysaccharidesAHIIL-27macrophagesmitochondrial dysfunctionsepsis

Identifiers

PMID40046257
PMCPMC11882325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.