Evidence map›Paper›PMID 40046208›Full record

ArticleNoro psikiyatri arsivi2025

Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment.

Xiaoling Yang, Miao Chen, Zuoting Shen, Tianyi Rong, Jialiang Feng, Min Wu, Deyan Chen, Zhenyu Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Noro psikiyatri arsivi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoling YangDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Miao ChenEmergency Department, The First Affiliated Hospital of Hainan Medical College, Hainan, China.
Zuoting ShenDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Tianyi RongDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Jialiang FengDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Min WuDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Deyan ChenDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Zhenyu WeiDepartment of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We investigated the effects of hyperbaric oxygen (HBO) therapy on post-stroke cognitive impairment (PSCI) and performed the differential profiling of lncRNAs and mRNA. Methods: The serum levels of different inflammatory factors were detected in PSCI patients with or without HBO therapy. The cognitive functions of patients in different groups were assessed before and after treatment. Differential expression analysis was performed on lncRNAs and mRNAs, followed by functional interaction prediction. The selected candidates were verified by Real-time Quantitative PCR and luciferase reporter assay. Results: The results of MMSE and MoCA scores showed that patients in both the control (conventional treatment) group and HBO therapy group had significantly higher post-treatment cognitive scores, and in the 6th month after treatment, patients in the HBO group had higher scores than those in the control group. Blood inflammatory factors showed similar results, with the HBO group having higher anti-inflammatory factors IL-4 and IL-10 than the control group, and lower pro-inflammatory factors IL-2, IL-6, TNF-α, IFN-α and IL-17A than the control group. We further identified a competitive endogenous RNA regulator network of LINC00205-hsa-miR-495-3p-TNFSF15 involved in the HBO treatment, and their expression patterns were verified by qRT-PCR. Conclusion: HBO treatment can improve the cognitive performance of PSCI patients in comparison to conventional treatment scheme. LINC00205/miR-495-3p/TNFSF15 axis may be responsible for the treatment effect of HBO therapy.

Indexed as

Bioinformatics analysisceRNAhyperbaric oxygenoxidative stressPost-stroke cognitive impairmentTNFSF15

Identifiers

PMID40046208
PMCPMC11877386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.