ArticleNoro psikiyatri arsivi2025
Evaluation of The Impact of Hypocretin Receptor 1 rs2271933 Polymorphism on Sleep Components in Chronic Migraine Patients with Poor Sleep Quality: A Subgroup Analysis.
Article in Noro psikiyatri arsivi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introductıon: Long-reported dual comorbidity between migraine and sleep disorders suggests that some gene variations may play a role in this relationship. Our previous study found an association between poor sleep quality and the G allele of the hypocretin receptor 1 (HCRTR1) rs2271933 gene in patients with chronic migraine (CM). This study aimed to examine the relationship of this gene with some sleep parameters. Methods: The present study was designed cross-sectional in the Mersin University Neurology Clinic between January 2000 and February 2018. Patients aged 18-75 years with CM according to the International Classification of Headache Disorders-3 (ICHD-3) criteria were included. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of the patients. Patients were divided into two groups according to PSQI scores <6 or ≥6. Genotyping was performed for the HCRTR1 rs2271933 gene. Results: Among the 100 patients with CM, only the data of those (n=67) with poor sleep quality were included in this study. The mean age of patients was 40.9±11.8%, and the female rate was 89.6%. We detected that increasing the time to fall asleep (p=0.369) and the rate of poor sleep quality (p=0.461) and also shortening sleep duration (p=0.016) with the increase of G allele carrier of HCRTR1 rs2271933 gene. Conclusıon: As the G allele carrier of the HCRTR1 rs2271933 gene increased, a shorter sleep duration was observed. This finding may contribute to studies on the physiological roles of orexins.
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