Evidence map›Paper›PMID 40046175›Full record

ReviewMedical cannabis and cannabinoids

The Pharmacology of Cannabinoids in Chronic Pain.

Alonso Cortez-Resendiz, Timothy J Leiter, Steven M Riela, Nicholas M Graziane, Wesley M Raup-Konsavage, Kent E Vrana

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medical cannabis and cannabinoids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alonso Cortez-ResendizDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Timothy J LeiterDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, USA.
Steven M RielaDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, USA.
Nicholas M GrazianeDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Wesley M Raup-KonsavageDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.
Kent E VranaDepartment of Pharmacology, Penn State College of Medicine, Hershey, PA, USA.

Funding

AI-based Mapping of Complex Cannabis Extracts in Pain PathwaysR01AT012053 · NCCIH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Nikolay Dokholyan, KENT E VRANA · 2023 to 2026
$2.4M
NCCIH NIH HHS R01 AT012053
6 · The paper itself

Abstract

Background: Our objective was to provide an overview of the currently available scientific and clinical data supporting the use of Summary: Evidence suggests that cannabis and cannabinoids have an analgesic effect that arises from a combination of compounds and various receptor systems. These effects may be maximized with the use of a combination of cannabinoids. At the same time, the combination of cannabinoids helps minimize the undesirable side effects of some cannabinoids such as the psychoactivity of THC. With these findings, further research is necessary to assess the analgesic properties of other cannabinoids like cannabichromene and cannabigerol and their contributions to the reduction of pain. Key Messages: Cannabis and its bioactive compounds show potential in the reduction of chronic pain.

Indexed as

CannabidiolCannabinoidsChronic painMedical cannabisTetrahydrocannabinol

Identifiers

PMID40046175
PMCPMC11882163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.