ReviewJournal of asthma and allergy2025
The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology.
Review in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- E3 ligase RNF145 regulates airway smooth muscle cell proliferation via the PP2A-p70S6K signaling axis.The Journal of biological chemistry · 2026Article
- E3 ubiquitin ligases and asthma relief.American journal of respiratory cell and molecular biology · 2026Article
- Ubiquitination regulates allergic asthma by affecting immune cells and immune responses.Biochemistry and biophysics reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma represents a major global health concern, underscoring an imperative for further exploration into its pathogenesis to inform the development of more effective treatment strategies. As a key mechanism for intracellular protein degradation and regulation, the ubiquitin-proteasome system (UPS) plays a crucial but complex and multifaceted role in the pathological process of asthma. This study systematically reviews the functions and mechanisms of E3 ubiquitin ligases and deubiquitinases within the UPS in asthma. The study explores the impact of these mechanisms on the occurrence of inflammation and the alteration of airway hyperresponsiveness by regulating the synthesis and release of inflammatory factors, as well as the proliferation or differentiation of key inflammatory cells. A comprehensive understanding of the pathological mechanism of UPS in asthma will help to provide new theoretical basis and potential drug targets for the precision treatment, which holds great promise for the treatment of asthma in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.