Evidence map›Paper›PMID 40046093›Full record

ArticleAquaculture nutrition2025

Branched-Chain Amino Acids Target miR-203a/fosb Axis to Promote Skeletal Muscle Growth in Common Carp (

Xianglin Cao, Han Cui, Xinyu Ji, Yaoyajie Lu, Qiuxia Kang, Ronghua Lu, Yuru Zhang, XinXin Xu, Jianjun Chen

Abstract read
In one paragraph

Article in Aquaculture nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xianglin CaoCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.
Han CuiCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.
Xinyu JiCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.
Yaoyajie LuCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Qiuxia KangCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.
Ronghua LuCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.ORCID https://orcid.org/0009-0001-9740-6028
Yuru ZhangCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.ORCID https://orcid.org/0000-0003-1480-9751
XinXin XuCollege of Fisheries, Henan Normal University, Xinxiang 453007, China.ORCID https://orcid.org/0000-0003-0019-0791
Jianjun ChenCollege of Life Science, Henan Normal University, Xinxiang 453007, China.ORCID https://orcid.org/0000-0002-8050-5900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starvation is an environmental stress that cannot be ignored during the growth of aquatic animals. Amino acid composition and balance can influence the nutritional effects, regulating the anabolic metabolism and energy signaling in the organism. Among these, branched-chain amino acids (BCAAs), which are essential amino acids in fish, play vital roles in energy regulation and growth metabolism. In order to observe the recovery effect of BCAAs in sustained duration starvation of common carp, a 4-week starvation period was initiated, followed by a 4-week feeding period with different concentrations of compound BCAAs (leucine:isoleucine:valine = 2:1:1). The detection of skeletal muscle protein deposition, muscle proliferation and differentiation, and indicators related to muscle atrophy at the conclusion of the culture period was conducted. Prior research has demonstrated that microRNA-203a (miR-203a) plays a role in the adaptive regulation of organisms under conditions of energy stress. To further investigate the target-related relationship among BCAAs, miR-203a, and FosB proto-oncogene, AP-1 transcription factor subunit (fosb), an in vitro transfection procedure was conducted in conjunction with topical injections of

Indexed as

branched-chain amino acidsfosbmicroRNA-203askeletal muscle growth and developmentstarvation stress

Identifiers

PMID40046093
PMCPMC11882326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.