ArticleFrontiers in immunology2025
Aberrant lipid profiles and lymphocyte counts in systemic sclerosis population, reassessing predictive value for concurrent cardiovascular diseases.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Classic lipid profile and lipoprotein(a) in systemic sclerosis: a systematic review and meta-analysis of case-control studies.Rheumatology international · 2025Pooled it
- Biomarker patterns across skin-lung-gut burden in systemic sclerosis.Frontiers in immunology · 2026Article
- Association of lipid parameters with the development of disease complications in patients with limited cutaneous systemic sclerosis: a prospective exploratory cohort study.Frontiers in nutrition · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate alterations in blood lipid profiles and T cell subsets among systemic sclerosis (SSc) patients, and to assess their potential utility in predicting cardiovascular disease (CVD) risk. Methods: 105 SSc patients and 80 age- and sex-matched healthy controls (HCs) were enrolled. Flow cytometry was employed to quantify T cell subsets. Multivariate logistic regression analysis investigated the association between blood lipid profile, T cell subsets, SSc occurrence, and CVD risk. Additionally, a prediction model was developed to assess the potential predictive value of CVD risk. Results: In the SSc patients, low-density lipoprotein cholesterol (LDL-C) (OR = 3.212, 95%CI = 1.132-9.113, Conclusion: Altered lipid profiles and dysregulated Th cell expression in SSc patients, with a significant elevation of Th cells specifically noted in SSc-CVD patients, suggesting that Th cells may serve as a potential predictive biomarker for CVD in SSc patients, thereby aiding in early diagnosis. The underlying mechanism of this association requires further investigation.
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