ArticleFrontiers in immunology2025
Cytokine profiles and CD4 counts in HIV-positive individuals with cysticercosis: implications for sex-specific immune responses in co-endemic regions of Tanzania.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Diagnostic Accuracy of Antigen ELISA and Western Blot IgG for Neurocysticercosis in People Living with HIV/AIDS in Tanzania.Tropical medicine and infectious disease · 2025Article
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12 authors.
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Abstract
Introduction: The interplay between HIV and Methods: We conducted a cross-sectional study involving 110 HIV-positive individuals. Cysticercosis was diagnosed using antibody and antigen tests, with neurocysticercosis confirmed by CT imaging. CD4 counts and serum cytokine levels (pro- and anti-inflammatory) were analyzed using multivariate regression and MANOVA, including sex-stratified analyses. Results: Among participants, 20.9% tested positive for cysticercosis antibodies, 43.6% for antigens and 20.2% presented with brain cysts, with 10.6% showing active neurocysticercosis. Cysticercosis-positive individuals showed positive correlations between CD4 counts and pro-inflammatory cytokines (e.g., TNF-α, IL-1β), contrasting with negative correlations in cysticercosis-negative individuals. Sex-stratified analysis showed stronger regulatory cytokine responses in males compared to females, particularly involving higher levels of IL-10 and IL-4 indicating sex-specific immune modulation in co-infected individuals. However, overall cytokine profiles were not significantly influenced by CD4 categories or cysticercosis status. Conclusion: These results contribute to our understanding of immunological interactions in HIV-cysticercosis co-infection and underscore the need for further research with larger sample sizes to elucidate the clinical implications of these findings. Such studies could inform the development of more effective, sex-personalized treatment strategies for HIV patients in cysticercosis-endemic regions.
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