Evidence map›Paper›PMID 40045941›Full record

ArticlePHAGE (New Rochelle, N.Y.)2024

Bacteriophage Dosing and Its Effect on Bacterial Growth Suppression in a

Jason Young, Mohammad Javad Shariyate, Ahmad Hedayatzadeh Razavi, Ara Nazarian, Edward K Rodriguez

Abstract read
In one paragraph

Article in PHAGE (New Rochelle, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason YoungHarvard Combined Orthopedic Residency Program, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9718-1797
Mohammad Javad ShariyateHarvard Medical School, Boston, Massachusetts, USA.
Ahmad Hedayatzadeh RazaviBeth Israel Deaconess Medical Center, Musculoskeletal Translational Innovation Initiative, Boston, Massachusetts, USA.
Ara NazarianHarvard Medical School, Boston, Massachusetts, USA.
Edward K RodriguezHarvard Medical School, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phages are an emerging therapy in the treatment of prosthetic joint infections, though many challenges remain, including an incomplete understanding of optimal phage dosing. Materials and Methods: We performed an Results: Planktonic bacterial growth was significantly higher when MOI ≤ 0.01 compared with MOI ≥ 10 ( Conclusions: Our findings suggest lower, not higher, phage dosing is associated with greater bacterial persistence. Our study helps inform the dosing and delivery of this alternative form of antibiosis.

Indexed as

bacteriophage dosingbacteriophagesbiofilmphage dosingphage therapyStaphylococcus epidermidis

Identifiers

PMID40045941
PMCPMC11876813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.