ReviewFrontiers in dental medicine2025
The impact of estrogen on periodontal tissue integrity and inflammation-a mini review.
Review in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- A systematic review and meta-analysis of the prevalence and risk factors of oral frailty among older adults.BMC oral health · 2026Pooled it
- Edentulism in China and the Group of Twenty (G20): Epidemiological Trends, Decomposition Analysis, and Forecasts to 2038.International dental journal · 2026Article
- Oral Health Across the Menopausal Transition: Biological Pathways, Clinical Implications, and Future Perspectives.Journal of clinical medicine · 2026Review
- A Pilot Study Assessing the Oral Microbiome in Women of Menopausal Age: Do Oral Nitrate-Reducing Bacteria Play a Role?International dental journal · 2026Observational
- Humic Acid Therapy Mitigates Estrogen Deficiency-Induced Alveolar Bone Loss and Modulates the RANKL/OPG Balance.Biomedicines · 2026Article
- The Silent Shift of Menopause: The Intersection between Salivary Glands, Oral Cavity Status, and Cardiovascular Health.Arquivos brasileiros de cardiologia · 2026Review
- Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss.Journal of cellular and molecular medicine · 2026Review
- Periodontitis Severity and Subgingival Microbiome Variation in Postmenopausal Women: A Stratified Case-Control Study.Life (Basel, Switzerland) · 2026Article
- Nutritional Biomarkers, Bone Turnover, and Oxidative DNA Damage in Postmenopausal Women with Periodontitis: A Cross-Sectional Study.Nutrients · 2026Article
- L-Quebrachitol Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption in Ovariectomized Rat Model.Biomolecules · 2026Article
- Evaluation of salivary bone turnover markers and vitamin D as non-invasive, early predictive indicators of bone health in pre-, peri-, and post-menopausal women.BMC women's health · 2026Article
- Salivary Antioxidant and Peroxidase Activity as a Marker of Steroid Hormone Receptor Expression in Breast Cancer.International journal of molecular sciences · 2026Article
- Adipose tissue inflammation mediated by CCL19 overexpression exacerbates experimental periodontitis via elevated circulating saturated fatty acids and osteopontin in Western-diet-fed mice.Frontiers in immunology · 2026Article
- Lifestyle clusters and bone mineral density in Chinese adults: a cross-sectional study with cluster analysis.Frontiers in endocrinology · 2026Article
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
- Exploratory Analysis of Sex-Related Immune Gene Expression in Patients With Severe Periodontitis.Balkan journal of medical genetics : BJMG · 2025Article
- Assessing the Oral Microbiome in Women of Reproductive Age: A Narrative Review.Clinics and practice · 2025Review
- Review
- Association of HLA-A alleles with periodontitis in people living with HIV: A case control study.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogen is said to be a crucial player in different aspects of periodontal health and disease, influencing a spectrum of cellular and molecular processes within periodontal tissues. Its receptors, ERα and ERβ, are expressed in various periodontal cells, suggesting direct responsiveness to hormonal fluctuations. Mechanistically, estrogen regulates osteoblast and osteoclast activity, thereby affecting bone turnover and maintenance of alveolar bone density. Studies indicate that estrogen upregulates the periodontal ligament stem cells' osteogenic differentiation (PDLSCs), promoting collagen synthesis and matrix mineralization critical for periodontal tissue integrity. Moreover, estrogen's anti-inflammatory properties modulate cytokine expression and immune responses in the periodontium, potentially attenuating periodontal inflammation and tissue destruction. Conversely, estrogen deficiency, such as in postmenopausal women, correlates with increased susceptibility to periodontal diseases characterized by greater clinical attachment loss and alveolar bone resorption. Hormone replacement therapy (HRT) with estrogen has shown promise in clinical settings, demonstrating beneficial effects on periodontal health by reducing inflammation and maintaining alveolar bone density. However, the adequacy and assurance of long-term estrogen supplementation in periodontal management require further investigation due to its systemic effects on other tissues and organs. Understanding the intricate interactions between estrogen and periodontal tissues is crucial for developing targeted therapies that leverage hormonal pathways to enhance periodontal health and mitigate disease progression effectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.