Evidence map›Paper›PMID 40045689›Full record

Trial reportCancer2025

The effect of online cognitive behavioral therapy for insomnia in adolescents and young adults after childhood cancer: Results from a randomized controlled trial.

Hinke van der Hoek, Shosha H M Peersmann, Heleen Maurice-Stam, Gertjan J L Kaspers, Esther M M van den Bergh, Wim J E Tissing, Leontien C M Kremer, Floor Abbink, Andrica C H de Vries, Jacqueline Loonen and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Bibliometric and visual analysis of cancer-related insomnia research from 2015 to 2025.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hinke van der HoekPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0002-0020-5036
Shosha H M PeersmannPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Heleen Maurice-StamPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Gertjan J L KaspersPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Esther M M van den BerghPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Wim J E TissingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Leontien C M KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Floor AbbinkEmma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Andrica C H de VriesPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jacqueline LoonenDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Annemieke van StratenDepartment of Clinical, Neuro, and Developmental Psychology, Faculty of Behavioural and Movement Science & Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Martha A GrootenhuisPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Raphaële R L van LitsenburgPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Funding

KWF Kankerbestrijding 10706
6 · The paper itself

Abstract

backgroundInsomnia is common during and after childhood cancer and associated with negative health outcomes and impaired quality of life. Many adolescents and young adults do not receive treatment. Internet-delivered cognitive behavioral therapy for insomnia (iCBT-i) can fill this gap. This study assesses the effectiveness of the iCBT-i intervention "iSleep youth".

methodsPatients (12-30 years old) with an Insomnia Severity Index ≥8, ≥6 months after treatment, and <10 years after diagnosis were 1:1 randomized to iSleep youth or the wait list-control group. iSleep youth consists of five online sessions with a coach. Outcomes were sleep efficiency (actigraph-based), insomnia, fatigue, and health-related quality of life (HRQOL). Differences over time between iSleep youth and controls, 3 months (T3) and 6 months (T6) from baseline, were assessed with linear mixed models, controlling for age, sex, and time since end of treatment. iSleep youth also had a follow-up measurement after 12 months (T12).

resultsFifty-four (response rate, 49%) patients participated: 68.9% females, mean age, 18.5 years (SD = 3.5), and mean time since end of treatment 3.8 years (SD = 2.3). No significant effects between the two groups were found for sleep efficiency. However, iSleep youth had a beneficial effect on insomnia severity at T3 (β = -0.79) and T6 (β = -0.55), on fatigue at T3 (β = -1.08) and T6 (β = -0.52) and on HRQOL at T3 (β = 0.46) and T6 (β = 0.62). The scores did not change from T6 to T12 in iSleep youth.

conclusionsiSleep youth is effective in treating insomnia and concurrent fatigue in adolescents and young adults after childhood cancer and should be implemented.

Indexed as

Cognitive Behavioral TherapyNeoplasmsSleep Initiation and Maintenance DisordersAdolescentAdultCancer SurvivorsChildFatigueFemaleHumansMaleQuality of LifeTreatment OutcomeYoung Adultcognitive behavioral therapyiCBT‐iinsomniaonline interventionpediatric oncologysleep

Identifiers

PMID40045689
PMCPMC11883199

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.