ArticleSe pu = Chinese journal of chromatography2025
[Open experiment: quantitative proteomics analysis of thyroid-cancer tissue slices using ultra-high performance liquid chromatography-tandem mass spectrometry].
Article in Se pu = Chinese journal of chromatography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Comprehensive analytical chemistry experiment： analysis of non-covalent interactions between double-stranded deoxyribonucleic acid and a natural drug by electrospray ionization mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Open experiments play crucial roles in developing undergraduate students' practical abilities, innovative thinking, and teamwork. This open experiment is designed to use ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in proteomics, a frontier field, by quantitatively analyzing thyroid-cancer-tissue-slice samples. Various reagents are first screened for further study by evaluating their abilities to extract proteins. This approach aims to foster students' hands-on abilities and their scientific-research thinking. The liquid-chromatography method is subsequently optimized to enable deep-coverage of the proteome, thereby enhancing students' understanding of liquid chromatography and mass spectrometry. Paraffin-embedded thyroid-cancer-tissue slices are finally subjected to quantitative proteomic analysis, resulting in the identification of 33 differentially expressed proteins, thereby demonstrating their potential use in disease-typing applications. This open experiment integrates theoretical and experimental knowledge gained through instrumental analysis, analytical chemistry, and biochemistry, thereby imparting scientific research thinking and innovative spirit to undergraduates. It also provides students with opportunities to expand and solidify theoretical knowledge through hands-on instrumental operation and experiments, which helps to build a systematic knowledge framework and develop a comprehensive understanding of relevant fields. Moreover, it stimulates undergraduate interest in scientific research, cultivates innovative thinking, and fosters team cooperation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.