ArticleAnimal bioscience2025
The impact of active components from Piper sarmentosum on the growth, intestinal barrier function, and immunity of broiler chickens.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dietary Chlorogenic Acid-Rich Green Coffee Bean Extract Improves Laying Performance and Antioxidant Status in Heat-Stressed Laying Hens.Animals : an open access journal from MDPI · 2026Article
- DietaryAntioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivePellitorine (PT) and vitexin-2-O-rhamnoside (VR) are two bioactive compounds found in Piper sarmentosum (PS). Their contents are relatively high in the ethanol extract of PS (PSE). However, it remains unknown whether PT and VR are the primary components of PS that exert beneficial effects on gut health. In this study, we aimed to confirm that these two compounds are the primary anti-inflammatory active ingredients in PSE.
methodsTotal of 300 female one-day-old Danzhou chickens were randomly divided into five groups with five replicates each. Chickens were given a basal diet (CON group), a basal diet with added PSE (200 mg/kg), VR (1.321 mg/kg), PT (0.563 mg/kg), and a combination of VR+PT (1.321 mg/kg VR and 0.563 mg/kg PT) until they reached 35 days of age.
resultsThe findings reveal that the VR+PT group exhibited increased liver, thymus and spleen indices compared to the CON group, along with elevated mRNA levels of ZO-1 and Claudin-1 (p<0.05). In contrast, the VR+PT group exhibited reduced serum levels and the ileum mucosa mRNA expression levels of IL-1β and IL-6 compared to the CON group (p<0.05). Additionally, the chickens in the VR+PT group had a greater final weight and average daily gain than those in the CON and PSE groups, with a significantly lower level of D-lactic acid in serum (p<0.05). The serum IgM level increased significantly (p<0.05) in the VR+PT group compared to the PSE group, while the kidney epinephrine level decreased significantly (p<0.05).
conclusionThe present study provides preliminary evidence that VR and PT are two of the main active compounds in PSE, which can cooperatively improve growth performance, intestinal barrier integrity, and immune function in chickens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.