ArticleJournal of acquired immune deficiency syndromes (1999)2025
Predictors of Acute HCV Incidence in People with HIV: Insights from a Long-term Cohort Study.
Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Glecaprevir/Pibrentasvir for Acute Hepatitis C Virus Infection in Individuals with a History of Prior Hepatitis C Infection.Infectious diseases and therapy · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundPersons living with HIV (PWH) remain at risk for hepatitis C virus (HCV) acquisition despite antiretroviral therapy, particularly among those who inject drugs or engage in high-risk sexual behaviors. We evaluated acute HCV incidence and associated risk factors in PWH, incorporating sex-specific differences and the use of Nucleic Acid Testing (NAT) methods, which were not addressed in previous analyses.
methodsWe assessed NAT-based HCV incidence from 1996-2011 in the ACTG ALLRT cohort, a long-term study of PWH after initiating antiretroviral therapy. Multivariable Poisson regression identified associations with self-reported injection drug use (IDU), and time-varying CD4+ count, HIV RNA level and increased ALT (grade ≥3). No sexual risk factors or non-IDU drug use data were available.
resultsAmong 4,015 PWH (18% women, n=703) with an initial negative HCV antibody result, there were 18,150 person-years (PY) of follow-up. Forty-two participants seroconverted, an incidence of 0.23 per 100 PY (95% CI: 0.17, 0.31). Incidence was lower in females (n=2) versus males (n=40; 0.06 vs 0.27 per 100 PY; p=0.04). Seroconversion was associated with time-updated HIV RNA ≥400 copies/mL (RR 2.7, 95% CI 1.4-5.1, p=0.003), time-updated grade ≥3 ALT (RR 4.7, 95% CI 1.6, 13.4, p=0.005), and IDU (RR 6.3, 95% CI 2.7, 14.4, p<0.001).
conclusionsOur analysis showed that IDU history and unsuppressed HIV RNA were associated with HCV acquisition among PWH. Elevated ALT levels are consistent with the biology of acute/recent hepatitis and should trigger HCV RNA testing. These findings emphasize the need for targeted interventions to reduce HCV transmission risk in PWH.
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