ArticleJournal of health, population, and nutrition2025
Ultra-processed foods and coronary artery disease severity: a cross-sectional study of at-risk normal-weight and overweight patients undergoing elective angiography.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- HDL-C as a potential mediator between serum 25(OH)D and the angiographic severity of coronary artery disease: a single-center cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
- Healthy diet scores and ultra-processed foods with incident coronary heart disease: a prospective study.Nutrition & metabolism · 2026Article
- The association between Dietary Fat Quality (DFQ) indices, coronary occlusion, and lipid profile among adults living in Central Iran.Lipids in health and disease · 2026Article
- Higher Dietary Insulinemic Potential, and Triglyceride-Glucose (TyG)-BMI Index may Contribute to Coronary Artery Disease Severity: a Cross-Sectional Study.Journal of epidemiology and global health · 2025Article
- Increased dietary acid load May elevate the risk of coronary artery disease severity: Findings from a cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Investigating the dietary inflammatory index and pro-inflammatory immune dynamics: insights from a cross-sectional study of severe vs. non-severe coronary artery disease patients.European journal of medical research · 2025Article
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6 authors.
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Abstract
introductionThere is growing interest in the connection between ultra-processed food (UPF) and cardiovascular diseases. This study explores how UPF intake relates to the severity of coronary artery disease (CAD) in at-risk patients undergoing elective angiography.
methodsData covering demographic, and clinical details, and dietary intakes (using a validated food frequency questionnaire) were gathered from the Nutrition Heshmat Registry (NUTHER) in Rasht, Iran. UPF consumption was evaluated using the NOVA food classification system, with the exception of core grain foods. The study comprised 1,015 participants, who were classified based on the severity of CAD using the Gensini score (severe-CAD = Gensini score ≥ 60). Logistic regression was used to analyze the odd ratio (OR) and 95%confidence interval (95%CI) for severe-CAD across UPF quartiles (percentage of energy), and for each 10% increase in UPF intake. Restricted cubic spline (RCS) regression was employed to explore nonlinear relationships between UPF and severe-CAD.
resultsFollowing controlling for potential confounders, normal-weight participants in the highest quartile of UPF exhibited about 5 times greater odds of severe-CAD than those in the lowest category (OR(95%CI): 5.01 (1.89, 13.29); P-for-trend = 0.002). Overweight/obese participants in the higher UPF quartiles had approximately 2-3.5 times greater odds for severe-CAD than those in the 1st quartile (ORs (95%CIs): 3rd quartile 1.91 (1.14, 3.21); and 4th quartile: 3.53 (2.07, 5.99); P-for-trend < 0.001). Each 10% increase in daily energy intake from UPF was associated with about 1.6-2 times increased severe-CAD risk among overweight/obese and normal-weight individuals (ORs (95%CIs) of 1.64 (1.28, 2.11), and 2.24 (1.24, 4.05), respectively). RCS analysis showed an upward trend toward higher UPF intake in relation to increased risk of severe-CAD (P-for-overall-trend < 0.0001; P-for-nonlinearity = 0.005).
conclusionThe findings obtained underscore a direct association between UPF and the risk of CAD progression among at-risk patients, independent of BMI. However, further prospective studies are essential to confirm these results and better understand this relationship.
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