Evidence map›Paper›PMID 40045389›Full record

ArticleJournal of medical case reports2025

Eosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report.

Sarah Jalloul, Johny Salem, Karam Karam, Clara Chamoun, Louis Chaptini

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Eosinophilic Esophagitis in the Middle East: Insight From a Comprehensive Systematic Review.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah JalloulDepartment of Gastroenterology, Faculty of Medicine, University of Balamand, El Koura, Balamand, Lebanon.
Johny SalemDepartment of Gastroenterology, Faculty of Medicine, University of Balamand, El Koura, Balamand, Lebanon.
Karam KaramDepartment of Gastroenterology, Faculty of Medicine, University of Balamand, El Koura, Balamand, Lebanon.
Clara ChamounDepartment of Pulmonary and Allergology, Faculty of Medicine, University of Balamand, El Koura, Balamand, Lebanon.
Louis ChaptiniDepartment of Gastroenterology, Faculty of Medicine, University of Balamand, El Koura, Balamand, Lebanon. louis.chaptini@fty.balamand.edu.lb.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEosinophilic esophagitis is a condition characterized clinically by symptoms related to esophageal dysfunction and histologically by a marked eosinophilic infiltrate in the esophageal mucosa. The most typical symptoms of eosinophilic esophagitis include intermittent dysphagia with episodic food impaction and heartburn with propensity for young individuals. The relationship between hiccups and eosinophilic esophagitis is unclear but has been described. CASE REPORT: We report a case of a 93-year-old Middle Eastern male presenting for longstanding treatment-refractory hiccups. Imaging with computed tomography of the chest and abdomen was unremarkable. An upper endoscopy was normal without any endoscopic finding to suggest eosinophilic esophagitis. Given his elevated peripheral eosinophil count, biopsies were taken from mid- and distal esophagus and revealed eosinophilic infiltration in the range of 15 eosinophils per high-power field, favoring a diagnosis of eosinophilic esophagitis. The hiccups resolved following the initiation of eosinophilic esophagitis treatment.

conclusionThis case underscores the need to consider the diagnosis of eosinophilic esophagitis in the setting of chronic refractory hiccups.

Indexed as

Eosinophilic EsophagitisHiccupAged, 80 and overBiopsyEsophagusHumansMaleTreatment OutcomeEosinophilic esophagitisPhrenic nerveRefractory hiccupsVagal nerve

Identifiers

PMID40045389
PMCPMC11884032

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