Evidence map›Paper›PMID 40045366›Full record

ArticleBehavioral and brain functions : BBF2025

Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats.

Lauren P Giesler, William T O'Brien, Jesse Bain, Gershon Spitz, Emily J Jaehne, Maarten van den Buuse, Sandy R Shultz, Richelle Mychasiuk, Stuart J McDonald

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Article in Behavioral and brain functions : BBF, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lauren P GieslerDepartment of Neuroscience, Monash University, Melbourne, Australia.
William T O'BrienDepartment of Neuroscience, Monash University, Melbourne, Australia.
Jesse BainDepartment of Neuroscience, Monash University, Melbourne, Australia.
Gershon SpitzDepartment of Neuroscience, Monash University, Melbourne, Australia.
Emily J JaehneDepartment of Psychology Counselling and Therapy, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Maarten van den BuuseDepartment of Psychology Counselling and Therapy, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Sandy R ShultzDepartment of Neuroscience, Monash University, Melbourne, Australia.
Richelle MychasiukDepartment of Neuroscience, Monash University, Melbourne, Australia.
Stuart J McDonaldDepartment of Neuroscience, Monash University, Melbourne, Australia. stuart.mcdonald@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMild traumatic brain injury (mTBI) poses a significant public health concern, particularly regarding repetitive injury, with outcomes ranging from acute neurobehavioral deficits to long-term impairments. While demographic factors like age and sex influence outcomes, the understanding of genetic contributions, particularly the role of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, remains limited. This study aimed to characterize acute effects of repetitive mTBI (rmTBI) in rats with the Val68Met SNP, the rodent equivalent of the human Val66Met, focusing on behavioral, fluid biomarker, and histological changes.

methodsUsing a closed-head injury model, rats underwent five mTBIs over consecutive days. Behavioral assessments included sensorimotor function, anxiety-like behavior, spatial learning and memory, and nociceptive response. Plasma neurofilament light (NfL) levels served as a biomarker of axonal injury and immunohistochemistry evaluated microglial activation.

resultsSensorimotor deficits and increased anxiety-like behavior were found in rats with rmTBI, but these changes were not affected by sex or genotype. Plasma NfL levels were higher in rmTBI compared with sham rats, with levels greater in female rmTBI when compared with male rmTBI rats. Microglial activation was observed in the hypothalamus of injured rats, but was not influenced by genotype or sex.

conclusionsWhile the Val68Met SNP did not significantly influence acute responses to rmTBI in this study, further investigation into alternative functional and pathophysiological outcomes, as well as long-term effects, is required.

Indexed as

Brain ConcussionBrain-Derived Neurotrophic FactorAnimalsAnxietyBehavior, AnimalBiomarkersDisease Models, AnimalFemaleMaleMicrogliaNeurofilament ProteinsPolymorphism, Single NucleotideRatsRats, Sprague-DawleyBdnf protein, ratBiomarkersBrain-Derived Neurotrophic Factorneurofilament protein LNeurofilament ProteinsBehaviorBiomarkerConcussionMicrogliaNeurofilament lightVal66Met

Identifiers

PMID40045366
PMCPMC11884142

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