Evidence map›Paper›PMID 40045344›Full record

ArticleExperimental hematology & oncology2025

Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage.

Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology & oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aurora BernalStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Vincent CuminettiStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Marc SerullaStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Adrian FloritStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Joanna KoniecznyStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Golnaz GolnarnikStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Yimeng ChenStem Cells, Ageing and Cancer Research Group, Centre of Embryology and Healthy Development, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0373, Oslo, Norway.
Marc FerréStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Samuel GeiselerStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Anders VikDepartment of Hematology, University Hospital of North Norway, 9019, Tromsø, Norway.
Randi OlsenAdvanced Microscopy Core Facility, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 9, 9019, Tromsø, Norway.
Lorena ArranzStem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway. lorena.arranz@medisin.uio.no.

Funding

Aakre-Stiftelsen Foundation 2016/9050Helse Nord RHF Strategisk-HN06-14HORIZON-MSCA-2022-DN-01 101119613Kreftforeningen 6765150Norges Forskningsråd 247596
6 · The paper itself

Abstract

The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. Sympathetic fibres innervate the BM and are components of the hematopoietic stem and progenitor cell (HSPC) niche [2]. Neuropathy of the HSPC niche is present and essential for disease development in experimental models of JAK2

Indexed as

Hematological cancersPeripheral nervous systemStem cell nicheSympathetic fibresTransmission electron microscopy

Identifiers

PMID40045344
PMCPMC11884145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.