Observational studyBMC cancer2025
Preoperative heart rate variability as a predictor of postoperative pneumonia and lung function recovery in surgical lung cancer patients: a prospective observed study.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Machine learning of intraoperative variables to test feasibility of multivariable prediction modelling for postoperative complications in thoracic surgery: a prospective cohort study.Journal of thoracic disease · 2026Article
- Vagal pathways and heart rate variability in recovery after caesarean delivery: a framework for multimodal autonomic-immune phenotyping.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe objective of this study was to evaluate the significance of preoperative heart rate variability (HRV) as a surrogate marker for vagus nerve activity in predicting the incidence of postoperative pneumonia (POP) and lung function recovery in patients undergoing lung cancer surgery.
methodA prospective observational study was conducted at a single center. Patients were categorized into two groups: the POP group, which included those who developed pneumonia post-surgery, and the non-POP group, comprising patients who did not experience POP.
resultsA total of 257 subjects met the inclusion criteria and were ultimately included in the study. 33 patients presented POP, accounting for 12.8% (33/257) of the patients. Logistic regression revealed that preRMSSD (OR: 0.812, 95%CI: 0.720-0.912, P = 0.001) and preHFP (OR: 0.990, 95%CI: 0.983-0.996, P = 0.002) were the independent factors for POP; receiver operating characteristic curve (ROC) analysis for predicting the occurrence of the POP revealed that the combination of BMI, preHFP and preRMSSD showed the positive diagnostic accuracy (AUC: 0.867, P < 0.001). A logistic regression analysis showed that HRV indicators including preRMSSD (OR: 0.937, 95%CI: 0.892-0.985, P = 0.010) and preHFP (OR: 0.995, 95%CI: 0.992-0.998, P = 0.001) were independent factors for well-recovery in FEV1% within postoperative 30 days. Similar results can be found in well-recovery in FVC% or DLCO%.
conclusionThese findings provided compelling evidence supporting the utility of HRV indicators in predicting both POP and postoperative lung function recovery among surgical lung cancer patients.
trial registrationChiCTR2400085997, registered in 24/06/2024.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.