Evidence map›Paper›PMID 40045319›Full record

ArticleChild and adolescent psychiatry and mental health2025

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Dan Long, Ting Yang, Jie Chen, Jie Zhang, Ying Dai, Li Chen, Feiyong Jia, Lijie Wu, Yan Hao, Ling Li and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dan LongChildren Nutrition Research Center, Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Ting YangChildren Nutrition Research Center, Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Jie ChenChildren Nutrition Research Center, Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Jie ZhangChildren Health Care Center, Xi'an Children's Hospital, Xi'an, 710043, China.
Ying DaiChildren Nutrition Research Center, Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Li ChenChildren Nutrition Research Center, Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China.
Feiyong JiaDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, 130021, China.
Lijie WuResearch Center for Child Development and Behavior, Harbin Medical University, Harbin, 150081, China.
Yan HaoDepartment of Pediatrics, Tongi Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ling LiDepartment of Children Rehabilitation, Hainan Women and Children's Medical Center, Haikou, 570100, China.
Xiaoyan KeThe Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210005, China.
Mingji YiDepartment of Child Health Care, The Affiliated Hospital of Qingdao University, Qingdao, 266555, China.
Qi HongMaternal and Child Health Hospital of Baoan, Shenzhen, Shenzhen, 518101, China.
Jinjin ChenDepartment of Child Health Care, Shanghai Children's Hospital, Shanghai, 200062, China.
Shuanfeng FangDepartment of Child Health Care, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, 450018, China.
Yichao WangNational Health Commission Key Laboratory of Birth Defect for Research and Prevention, Hunan Maternal and Child Health Hospital, Changsha, 410008, China.
Qi WangDeyang Maternal and Child Health Hospital, Deyang, 618000, China.
Chunhua JinDepartment of Children Health Care, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, 100020, China.
Tingyu LiChildren's Hospital of Chongqing Medical University, Chongqing, 400014, China. tyli@vip.sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMotor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

methodsWe recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP). We investigated the overall status of neurodevelopment in preschool children with ASD through the Revised Children Neuropsychological and Behavior Scale (CNBS-R2016) and the Gesell Developmental Scale (GDS). The multivariate ordered logistic regression model was used to analyze the relationship between different degrees of motor developmental delay and demographic, core symptoms of ASD, and maternal risk factors, which were evaluated using the questionnaires, the Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale-Second Edition (SRS-2).

resultsThe proportions of delayed development in various neurodevelopmental domains was significantly imbalanced in preschool children with ASD. The proportions of gross and fine motor developmental delay were as high as 39.6% and 68.4% respectively. ASD children in different age subgroups all exhibited gross and fine motor developmental delay. The CARS and SRS-2 total scores of ASD children with mild, moderate-severe gross or fine motor developmental delay were significantly higher than those with normal motor skills development (P < 0.05). ASD children aged ≥ 5 years, or higher CARS and SRS-2 total scores, or gestational age in the 28-36

conclusionGross and fine motor developmental delay were difficulties that most preschool children with ASD may face, and ASD children with motor developmental delay had greater deficits in social skills. Therefore, it is necessary to continuously monitor the gross and fine motor development progress of children with ASD for facilitating early identification and individualized intervention.

Indexed as

AgeAutism spectrum disordersCore symptomsMaternal risk factorsMotor developmental delay

Identifiers

PMID40045319
PMCPMC11884192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.