Evidence map›Paper›PMID 40045310›Full record

Observational studyRespiratory research2025

Multicentre, real-world data of next-generation computer-assisted vacuum aspiration thrombectomy in acute pulmonary embolism.

Sylwia Sławek-Szmyt, Jakub Stępniewski, Marcin Kurzyna, Jacek Klaudel, Wiktor Kuliczkowski, Maciej Lewandowski, Marek Grabka, Marek Roik, Rasa Ordiene, Stanisław Jankiewicz and 8 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04879069 (Polish Multicenter Pulmonary Embolism Response Teams Outcomes Registry), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04879069 recruitingnot on this map

Polish Multicenter Pulmonary Embolism Response Teams Outcomes Registry

TypeobservationalSponsorPoznan University of Medical SciencesRan2018 to 2030Enrolled10,000ConditionsPulmonary Embolism With Acute Cor Pulmonale
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sylwia Sławek-Szmyt1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland. s.slawekszmyt@gmail.com.
Jakub StępniewskiDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Marcin KurzynaDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology European Health Centre Otwock, Medical Centre for Postgraduate Education, Otwock, Poland.
Jacek KlaudelDepartment of Cardiology, St. Adalbert's Hospital, Gdansk, Poland.
Wiktor KuliczkowskiDepartment of Cardiology, Wroclaw Medical University, Wroclaw, Poland.
Maciej LewandowskiClinic of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Marek Grabka1st Department of Cardiology, Silesian Medical University, Upper Silesian Medical Centre, Katowice, Poland.
Marek RoikDepartment and Faculty of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Rasa OrdieneDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Stanisław Jankiewicz1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Grzegorz KopećDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Szymon DarochaDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology European Health Centre Otwock, Medical Centre for Postgraduate Education, Otwock, Poland.
Ewa MroczekDepartment of Cardiology, Wroclaw Medical University, Wroclaw, Poland.
Katarzyna WideckaClinic of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Paweł KurzynaDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology European Health Centre Otwock, Medical Centre for Postgraduate Education, Otwock, Poland.
Maciej Lesiak1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Piotr PruszczykDepartment and Faculty of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Aleksander Araszkiewicz1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on interventional treatment of intermediate-high (and high-risk pulmonary embolism (PE) are limited. The authors sought to evaluate the safety and efficacy of catheter-directed mechanical aspiration thrombectomy (CDMT) in a real-world PE patient population.

methodsThis multicenter, prospective registry enrolled PE patients treated with CDMT using the Lightning 12 System. The primary safety endpoints included in-hospital all-cause mortality, procedure-related major bleeding, clinical deterioration, or bailout to another strategy. The primary efficacy outcomes included the reduction of pulmonary arterial pressures and change in the right-to-left ventricular (RV/LV) ratio 48 h after the CDMT. Multivariate regression analyzed characteristics associated with RV/LV improvement.

resultsOur analysis included 150 patients, 72% with intermediate-high PE and 28% with high-risk PE. Systemic thrombolysis was contraindicated in 33.3%, whereas in 4% it failed. There were 2% intraprocedural deaths (1.3% due to RV failure and 0.7% due to massive interstitial bleeding), with no more deaths during follow-up. In 0.7%, CDMT was converted to open surgery, and in 0.7%, bailout systemic thrombolysis and extracorporeal oxygenation support. Major bleedings occurred in 1.3% within 48 h post CDMT. Immediate hemodynamic improvements included a mean 11.3±10 mmHg (22.1%) drop in systolic pulmonary arterial pressure (p < 0.0001) and a median 0.33 (0.25-0.45), (25.2%) drop in RV/LV ratio (p < 0.0001 for paired values),

conclusionsAspiration thrombectomy with the Lightning 12 system characterizes an acceptable safety profile, substantial improvements in hemodynamic outcomes, and low mortality for patients with intermediate-high and high-risk PE.

trial registrationNCT04879069 - date of registration 04.05.2021.

Indexed as

Pulmonary EmbolismSurgery, Computer-AssistedThrombectomyAcute DiseaseAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesRegistriesTreatment OutcomeVacuumHigh-risk catheter-directed mechanical thrombectomyIntermediate-high riskPercutaneous thrombectomyPulmonary embolism

Identifiers

PMID40045310
PMCPMC11883934

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.