Evidence map›Paper›PMID 40045118›Full record

ArticleNature metabolism2025

Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations.

Hsuan-Chia Chang, Chung-Ying Tsai, Cheng-Lung Hsu, Tzong-Shyuan Tai, Mei-Ling Cheng, Yu-Ming Chuang, Hsiang-Yu Tang, Kun-Ju Lin, Jia-Jin Chen, Szu-Han Chang and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Hsuan-Chia Chang *Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0003-3478-5777
Chung-Ying Tsai *Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Cheng-Lung Hsu *Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Tzong-Shyuan TaiAdvanced Immunology Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0003-0575-914X
Mei-Ling ChengDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0003-2006-133X
Yu-Ming ChuangDepartment of Oncology, University of Lausanne, Lausanne, Switzerland.
Hsiang-Yu TangMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0002-2536-6370
Kun-Ju LinHealthy Aging Research Center, Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jia-Jin ChenKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Szu-Han ChangDepartment of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yi-Ching KoKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yu-Wen ChiKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0009-0009-8803-4435
Hsuan LiuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Bertrand Chin-Ming TanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chia-Rui ShenDepartment of Neurosurgery, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chih-Wei YangKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ping-Chih HoDepartment of Oncology, University of Lausanne, Lausanne, Switzerland. ping-chih.ho@unil.ch.ORCID http://orcid.org/0000-0003-3078-3774
Huang-Yu YangKidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. hyyang01@gmail.com.ORCID http://orcid.org/0000-0001-6826-9717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical studies have shown that asparagine deprivation enhances T cell antitumour responses. Here we apply compassionate use of L-asparaginase, usually employed to treat blood malignancies, on patients with recurrent metastatic nasopharyngeal carcinoma. The use of L-asparaginase notably enhances immune-checkpoint blockade therapy in patients by strengthening CD8

Indexed as

AsparaginaseAsparagineCD8-Positive T-LymphocytesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsReactive Oxygen SpeciesT-LymphocytesHumansSignal TransductionAsparaginaseAsparagineReactive Oxygen Species

Identifiers

PMID40045118
PMCPMC12116382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.