Evidence map›Paper›PMID 40045105›Full record

ArticleJournal of neuro-oncology2025

Spatial invasion patterns of temporal lobe glioblastoma after complete resection of contrast-enhancing tumor.

Jawad Fares, Yizhou Wan, Binay Gurung, Thaaqib Nazar, Richard Mair, Alexis Joannides, Thomas Santarius, Tomasz Matys, Stephen J Price

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jawad FaresCambridge Brain Tumour Imaging Laboratory, Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jf751@cam.ac.uk.ORCID http://orcid.org/0000-0002-5368-8764
Yizhou WanCambridge Brain Tumour Imaging Laboratory, Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Binay GurungAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Thaaqib NazarAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Richard MairAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Alexis JoannidesAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Thomas SantariusAcademic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Tomasz MatysDepartment of Radiology, University of Cambridge, Cambridge, UK.
Stephen J PriceCambridge Brain Tumour Imaging Laboratory, Academic Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Funding

Cancer Research UK Clinical Research FellowshipNational Institute for Health and Care Research NIHR203312Royal College of Surgeons of England Clinical Research Fellowship
6 · The paper itself

Abstract

purposeThis study investigated invasion patterns of temporal lobe glioblastoma following complete resection of contrast-enhancing tumor and evaluated whether non-enhancing tumor presence in the anterior temporal tip predicts the site of progression.

methodsWe retrospectively analyzed patients from a single-institution database who were diagnosed with IDH-wildtype temporal lobe glioblastoma and underwent complete resection of the contrast-enhancing region. Eligible patients had preoperative, immediate postoperative, and progression MRIs to assess tumor progression patterns. FLAIR imaging was examined for its predictive value in identifying progression sites. Surgical outcomes, progression-free survival (PFS), and overall survival were analyzed.

resultsA total of 48 patients were identified, of whom 14 (29%) underwent anterior temporal lobectomy and were excluded from further analysis. Among the remaining 34 patients, 21 (62%) exhibited anterior progression. Expert assessment suggested that in 12 of these 21 patients (57%), an anterior temporal lobectomy might have encompassed the region of tumor progression. Superior, inferior, and lateral progression patterns were associated with longer median PFS (~ 11 months), whereas medial progression correlated with the shortest PFS (5.9 months). FLAIR signal at the temporal tip had moderate sensitivity (71.43%) but low specificity (18.52%) for predicting anterior progression, resulting in a high false-positive rate.

conclusionsTemporal lobe glioblastomas often progress anteriorly, suggesting that anterior temporal lobectomy may help reduce progression in select cases. FLAIR imaging had limited predictive value for anterior progression, emphasizing the need for advanced imaging techniques. Future research should identify reliable biomarkers and evaluate the role of anterior temporal lobectomy through well-designed prospective studies.

Indexed as

GlioblastomaTemporal LobeAdultAgedAnterior Temporal LobectomyDisease ProgressionFemaleHumansMaleMiddle AgedNeoplasm InvasivenessRetrospective StudiesSurvival RateAnterior temporal lobectomyDiffusion tensor imagingFLAIRGlioblastomaIsocitrate dehydrogenase-wildtypeMagnetic resonance imagingSupramaximal resectionTemporal lobe

Identifiers

PMID40045105
PMCPMC12106570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.