Evidence map›Paper›PMID 40045071›Full record

Observational studyEuropean radiology2025

Prevalence and prognostic significance of reduced myocardial perfusion reserve in diabetic heart failure with preserved ejection fraction using quantitative perfusion cardiac magnetic resonance.

Yang Yang, Donglu Qin, Chenyu Li, Leting Tang, Shuai Wang, Xiaoman Chen, Daoquan Peng, Mu Zeng, Bilian Yu

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Quantitative myocardial blood flow and perfusion reserve with exercise cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang YangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Donglu QinDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Chenyu LiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Leting TangDepartment of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Shuai WangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xiaoman ChenDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Daoquan PengDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Mu ZengDepartment of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China. zengmu@csu.edu.cn.
Bilian YuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China. yubilian@csu.edu.cn.ORCID http://orcid.org/0000-0002-5701-5487

Funding

China Heart House-Chinese Cardiovascular Association TCM fund 2022-CCA-TCM-049Chinese Cardiovascular Association-ASCVD fund 2023-CCA-ASCVD-016National Natural Science Foundation of China 81701660National Natural Science Foundation of China 82170483Natural Science Foundation of Hunan Province of China 2023JJ40869The Scientific Research Program of FuRong Laboratory 2023SK2107
6 · The paper itself

Abstract

objectivesTo use cardiac magnetic resonance (CMR) to quantify coronary microvascular function, explore the relationship between perfusion and fibrosis, and assess the impact of coronary microvascular dysfunction (CMD) on adverse clinical outcomes. MATERIALS AND

methodsIn a prospective, observational study, patients with type 2 diabetes mellitus (T2DM) and heart failure were recruited alongside control subjects. Participants underwent clinical assessment and CMR, which included T1 mapping, extracellular volume mapping, as well as measurement of myocardial blood flow at rest and during maximal hyperaemia. Primary outcomes were all-cause death or hospitalization with a cardiovascular cause.

resultsOf 202 participants included, 55 T2DM patients were categorized as heart failure with preserved ejection fraction (DM-HFpEF), 70 as heart failure with ejection fraction less than 50% (DM-HFrEF/HFmrEF), 42 as T2DM control subjects (DM-control) and 35 as asymptomatic control group. DM-HFpEF group exhibited a comparatively diminished myocardial perfusion reserve (MPR) than other three cohorts (all p < 0.05). Reduced MPR (< 2.0) was present in 81.82% of patients with DM-HFpEF. MPR was associated with cardiac troponin T and diffuse fibrosis. MPR demonstrated independent predictability of adverse outcomes even adjusting for clinical, blood, and imaging parameters. Patients with lower MPR exhibited a higher risk of adverse outcomes.

conclusionsIn symptomatic patients with T2DM, a high prevalence of impaired MPR was observed specifically in individuals with HFpEF. MPR was associated with markers of myocardial injury and fibrosis and was predictive of adverse clinical outcomes. These findings could help identify high-risk patients, leading to more intensive treatment. KEY POINTS: Question Data on cardiac MRI for quantifying myocardial blood flow in diabetic patients with heart failure with preserved ejection fraction are limited. Findings A markedly impaired myocardial perfusion reserve was observed in diabetic patients with heart failure with preserved ejection fraction. Clinical relevance Myocardial blood flow could provide incremental value in the diagnosis and risk stratification in diabetic patients with heart failure with preserved ejection fraction.

Indexed as

Diabetes Mellitus, Type 2Heart FailureMagnetic Resonance ImagingMyocardial Perfusion ImagingAgedCoronary CirculationFemaleHumansMaleMiddle AgedPrevalencePrognosisProspective StudiesStroke VolumeDiabetes mellitusHeart failure with preserved ejection fractionMagnetic resonance imagingMicrocirculationMyocardial perfusion imaging

Identifiers

PMID40045071

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.