ArticleMikrochimica acta2025
Label-free electrochemical biosensor based on AuNPs and PCL-b-PHEAA amphiphilic copolymer for highly sensitive detection of CEA.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Electrochemical Biosensors for Cancer Diagnosis and Prognosis Using Protein Biomarkers: Current Trends, Advances, and Clinical Translation Potential.Sensors (Basel, Switzerland) · 2026Review
- Aptamers as target-specific recognition elements in drug delivery.Advanced drug delivery reviews · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker expressed in various human cancers. In this study, the electrode loaded with AuNPs was used to replace the traditional electrode, providing more active sites for biological probes and significantly enhancing the sensitivity of the sensor. By constructing an aptamer-antigen-aptamer "sandwich structure," highly selective detection was achieved, effectively avoiding cross-reactions. In addition, the polymer PCL-b-PHEAA was introduced for signal amplification, further improving the detection performance. The label-free method directly utilizes the biological recognition system to obtain more accurate information and is more convenient to operate. Under the optimal conditions, the linear range of CEA detection by electrochemical impedance method was 100 fg mL
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