Evidence map›Paper›PMID 40045031›Full record

ArticleNature immunology2025

A critical role of N

Lu Sun, Xiaoyan Li, Feixiang Xu, Yuwen Chen, Xushuo Li, Zhicheng Yang, Ying Yang, Ke Wang, Tianyi Ren, Zihao Lin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. The NAT10/acCell communication and signaling : CCS · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Functional roles and mechanisms of NAT10-mediated RNA acFrontiers in cell and developmental biology · 2026
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lu Sun *Shanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoyan Li *Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Feixiang Xu *Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuwen ChenJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Xushuo LiJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Zhicheng YangJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Ying YangJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Ke WangJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Tianyi RenDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zihao LinJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Hua WangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID http://orcid.org/0000-0002-2605-5697
Xiangdong WangShanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai, China.
Yan LuInstitute of Metabolism and Regenerative Medicine, Digestive Endoscopic Center, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. luyan5011@shsmu.edu.cn.ORCID http://orcid.org/0000-0003-3468-2241
Zhenju SongShanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai, China. song.zhenju@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0001-9294-8824
Zhou-Li ChengJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, China. chengzhouli@fudan.edu.cn.ORCID http://orcid.org/0009-0002-1961-534X
Duojiao WuShanghai Key Laboratory of Lung Inflammation and Injury, Zhongshan Hospital, Fudan University, Shanghai, China. wu.duojiao@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-2562-8825

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82273188Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 20Y11900100
6 · The paper itself

Abstract

Following activation, naive T cells exit quiescence and require global translation for rapid expansion, yet the underlying mechanisms remain unclear. Here, we show that during T cell activation, cells upregulate the expression of N-acetyltransferase 10 (NAT10), an enzyme responsible for N

Indexed as

AcetyltransferasesCytidineLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusRNA, MessengerT-LymphocytesAcetylationAnimalsCell ProliferationHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene Proteins c-mycAcetyltransferasesCytidineProto-Oncogene Proteins c-mycRNA, Messenger

Identifiers

PMID40045031
PMCPMC11957992

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.