ArticleJournal of bone and mineral metabolism2025
Associations between hormones, metabolic markers, and bone mass in perimenopausal and postmenopausal women.
Article in Journal of bone and mineral metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between immune-inflammatory index and osteoporosis: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Comparison of efficacy of acupuncture-related therapy in the treatment of perimenopausal obesity: a network meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Burden of fall-related fracture among postmenopausal women: findings from the global burden of disease study 2021.Aging clinical and experimental research · 2026Article
- Using subject-level variability to predict time-varying outcomes: investigating the association between hormone variability and BMD trajectories over the menopausal transition.Journal of applied statistics · 2026Article
- Beyond Estrogen Deficiency: The Independent Role of FSH in Site-Specific Bone Loss in Midlife Women.Calcified tissue international · 2025Article
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6 authors.
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Abstract
introductionTo explore the associations between hormones, metabolic markers, and low bone mass in perimenopausal and postmenopausal women. MATERIALS AND
methodsA total of 198 women were enrolled in this study. The correlations between hormones, metabolic markers, and BMD were analyzed. Risk factors for bone loss were identified. Receiver operating characteristic (ROC) curves were used to display the predictive power of these risk factors.
resultsThe years since menopause and the levels of glucose (GLU), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were inversely correlated with BMD, while estrogen and testosterone were positively correlated with BMD. Age (odds ratio [OR] 1.232; 95% confidence interval [CI] 1.106-1.372; p < 0.001), GLU (OR 1.848; 95% CI 1.116-3.059; p = 0.017), and FSH (OR 1.089; 95% CI 1.003-1.182; p = 0.042) were identified as risk factors for bone loss. Age (AUC = 0.884, 95% CI 0.833-0.935), FSH (AUC = 0.824, 95% CI 0.760-0.888), and GLU (AUC = 0.683, 95% CI 0.599-0.768) demonstrated significant discrimination capability for bone loss. The combined application of these factors resulted in a better prediction effect (AUC = 0.930, 95% CI 0.893-0.967).
conclusionsAge, FSH, and GLU were found to be specific risk factors for bone loss. The utilization of these factors offers compelling predictive power for bone loss in perimenopausal and postmenopausal women.
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