Evidence map›Paper›PMID 40044869›Full record

ArticleNature2025

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide.

Laetitia Coassolo, Niels B Danneskiold-Samsøe, Quennie Nguyen, Amanda Wiggenhorn, Meng Zhao, David Cheng-Hao Wang, David Toomer, Jameel Lone, Yichao Wei, Aayan Patel and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026
    Review
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  3. Review
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  7. Review
  8. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
    Review
  9. Review
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Laetitia CoassoloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Niels B Danneskiold-SamsøeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Quennie NguyenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0003-2604-8256
Amanda WiggenhornDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9413-690X
Meng ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5415-8335
David Cheng-Hao WangDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
David ToomerDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0001-3712-5689
Jameel LoneDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Yichao WeiDepartments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Aayan PatelDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Irene LiparuloDepartment of Nutrition and Toxicology, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-2069-0067
Deniz KaviDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Lianna W WatDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6998-0594
Saranya Chidambaranathan ReghupatyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Julie Jae KimDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Tina AsemiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ewa Bielczyk-MaczynskaThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Veronica L LiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8888-3853
Maria Dolores Moya-GarzonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Nicole A J KrentzDivision of Endocrinology, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Andreas StahlDepartment of Nutrition and Toxicology, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-9096-3024
Danny Hung-Chieh ChouStanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9110-614X
Liqun LuoDepartment of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5467-9264
Katrin J SvenssonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. katrinjs@stanford.edu.ORCID 0000-0001-5376-5128

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Molecular Pharmacology Training GrantT32GM113854 · NIGMS · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2015 to 2019
$1.1M
Animal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational NeuroscienceS10OD030452 · OD · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2021 to 2021
$743k
Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
American Heart Association-American Stroke Association 23IPA1042031NIAMS NIH HHS K99 AR081618NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK125260NIGMS NIH HHS T32 GM113854NIH HHS S10 OD030452
6 · The paper itself

Abstract

Peptide hormones, a class of pharmacologically active molecules, have a critical role in regulating energy homeostasis. Prohormone convertase 1/3 (also known as PCSK1/3) represents a key enzymatic mechanism in peptide processing, as exemplified with the therapeutic target glucagon-like peptide 1 (GLP-1)

Indexed as

Anti-Obesity AgentsObesityPeptidesProteolysisAnimalsBody WeightDrug DiscoveryEatingFemaleGlucagon-Like Peptide-1 ReceptorHumansLeptinMaleMiceMice, Inbred C57BLPeptide FragmentsAnti-Obesity AgentsGlucagon-Like Peptide-1 ReceptorLeptinPeptide FragmentsPeptide HormonesPeptidesProprotein Convertase 1Proto-Oncogene Proteins c-fosReceptor, Melanocortin, Type 4

Identifiers

PMID40044869
PMCPMC12043402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.